Table 1.

Recent laboratory findings indicating links between autophagy and IBD

Treatment	Outcome	Reference
Slit2/Robo1	Activated autophagy in intestinal stem cells and mitigated DSS-induced UC	Xie et al., 2020
Dapagliflozin	Increased colonic autophagy and suppressed apoptosis in a TNBS-induced rat colitis model	Arab et al., 2021
TREM-1 inhibitor	Restored impaired autophagy and alleviated colitis in mice	Kokten et al., 2018
IL-33	Reduced TNBS-induced colitis in mice by promoting mitophagy	Wang et al., 2019
Celastrol	Augmented NLRP3 inhibitor (CP-456773) activity through heat shock protein-90 and increased autophagy in rats with DSS-induced colitis	Saber et al., 2020
Curcumin	Prevented the development of DSS-induced colitis in mice through inhibition of excessive autophagy and regulation of the subsequent cytokine network	Yue et al., 2019
Herb-Partitioned Moxibustion	Attenuated intestinal inflammation and promoted the repair of colon mucosal injury in rats with CD while downregulating the autophagy-associated NOD2 and IRGM genes	Zhao et al., 2019
Resveratrol	Increased autophagosome levels, decreased inflammatory cytokine levels, and alleviated UC-related intestinal mucosal barrier dysfunction in mice with DSS-induced colitis	Pan et al., 2020

Robo1, roundabout homolog 1; DSS, dextran sulfate sodium; UC, ulcerative colitis; TNBS, 2,4,6-trinitrobenzene sulfonic acid; TREM1, triggering receptor expressed on myeloid cells 1; IL-33, interleukin-33; NLRP3, NOD-, LRR-, and pyrin domain-containing protein 3; CD, Crohn’s disease.