Table 6.
Inhibitory effect of BSAAs 6c, 6i, 10a and 11a against selected kinases.
| Residual enzymatic activity (%)b |
|||||
|---|---|---|---|---|---|
| Cpd.a | Src | Abl | Fyn | PI3Kα | CDK9/cT1 |
| 6c | 45.0 ± 20.0 | 54.0 ± 4.0 | NAc | 69.0 ± 1.0 | 87.0 ± 14.0 |
| 6i | 47.0 ± 20.0 | 70.0 ± 10.0 | NA | 66.0 ± 0.2 | NA |
| 10a | 84.0 ± 1.0 | 67.0 ± 2.0 | NA | 77.0 ± 3.2 | 88.0 ± 10.0 |
| 11a | NA | NA | 89.0 ± 2.0 | 78.0% ± 0.3 | NA |
| 3 | 59.0 ± 9.4 | 65.0 ± 5.6 | 45.0 ± 6.9 | ND | NA |
a
Each compound was tested at fixed 5 μM concentration. Values for reference compound 3 reported from the literature.
b
Values are the mean ± SD of two independent experiments.
c
NA: residual enzymatic activity >98%.