Table 1.

Characteristics of the 10 studies included in the meta-analysis

Authors	Publication year	Country	Study design	No. of patients	Length of follow-up (wk)	Mean age (y)	No. of male	No. of female	Mean BMI	Median CD4 cell count (cells/μL)	Median HIV-1 RNA viral load-log10 (copies/ml)	Patients with TB at enrolment	Days on tuberculosis therapy at ART start	Incidence of TB-Associated IRIS	Deaths of all-cause
Abdool Karim SS et al.	2011	South Africa	Randomized clinical trial, RCT	429	18	34	209	220	26	152	5	429	28	61	30
Havlir DV et al.	2011	USA	Randomized clinical trial, RCT	806	48	34	501	305	19	76	5.4	374	14	61
Blanc FX et al.	2011	Cambodia	Randomized clinical trial, RCT	661	50	35	425	236	17	25	5.7	661	14/56	155	149
Manosuthi W et al.	2012	Thailand	Randomized clinical trial, RCT	156	54	38	121	35	19	45	5.7	156	28/84	81	11
Sinha S et al.	2012	India	Randomized clinical trial, RCT	150	54	35	126	24	18	140	5.3	150	14-28/56-84	15	16
Laureillard D et al.	2013	Cambodia	Randomized clinical trial, RCT	597	48	36	385	212	18	26	5.6	530	14/56	155
Mfinanga SG et al.	2014	South Africa	Randomized clinical trial, RCT	1675	24	32	922	616	19	367		1675	14/180	171	63
Amogne W et al.	2015	Ethiopia	Randomized clinical trial, RCT	478	8	36	245	233	19	72	5.2	478	7/28/56	22	64
Haridas V et al.	2015	Cambodia	Randomized clinical trial, RCT	154	48							154	14/56	50
Meintjes G et al.	2018	South Africa	Randomized clinical trial, RCT	120	12	36	73	47	21	49	5.6	89	30	56