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. 2021 Mar 17;44(7):813–821. doi: 10.1038/s41440-021-00629-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Performance of the sFlt-1/PlGF ratio for predicting preeclampsia/MAO/FAO within 1 week and within 4 weeks.^a A shows the distribution of sFlt-1/PlGF ratios at baseline and p values for participants who developed or did not develop preeclampsia/MAO/FAO within 1 week and within 4 weeks.^b B shows the performance of the ratio for predicting preeclampsia/MAO/FAO within 1 week (blue) and within 4 weeks (orange). ^a175 participants from Japan were eligible for this analysis. ^bBoxes represent the median and interquartile range; the lower whisker represents the larger of the minimum ratios and the 25th quartile to 1.5× interquartile range, while the higher whisker represents the smaller of the maximum ratios and the 75th quartile to 1.5× interquartile range, in log-scale. AUC area under the curve, CI confidence interval, FAO fetal adverse outcome, MAO maternal adverse outcome, PlGF placental growth factor, sFlt-1 soluble fms-like tyrosine kinase 1