Table 3. Comparison of the color differences between cancers and their surrounding mucosa on WLI, BLI-bright, BLI, and LCI (n=40).
| Variables | P-value | |||||
|---|---|---|---|---|---|---|
| ⊿E | ||||||
| White Light Images | 7.0 (5.2 to 9.0) | |||||
| BLI-bright with C1 | 9.1 (6.3 to 13.1) | vs. WLI <0.001 | ||||
| BLI-bright with C2 | 10.7 (7.2 to 14.4) | vs. WLI <0.001 | ||||
| BLI with C1 | 10.1 (6.7 to 13.1) | vs. WLI <0.001 | ||||
| BLI with C2 | 11.6 (8.3 to 16.7) | vs. WLI <0.001 | ||||
| LCI with C1 | 13.8 (9.6 to 16.8) | vs. WLI <0.001 | ||||
| LCI with C2 | 12.2 (9.7 to 16.4) | vs. WLI <0.001 | ||||
| Color enhancement | C1 | C2 | ||||
| BLI-bright | ||||||
| ⊿E | 10.0 (6.4 to 13.3) | 10.7 (8.0 to 14.7) | 0.033 | |||
| ⊿L | −3.4 (−9.0 to 1.8) | −4.7 (−9.5 to 3.5) | 0.472 | |||
| ⊿a | 4.4 (2.9 to 7.6) | 5.4 (2.9 to 7.4) | 0.291 | |||
| ⊿b | 1.8 (−0.1 to 3.5) | 1.2 (−0.3 to 3.6) | 0.301 | |||
| BLI | ||||||
| ⊿E | 10.4 (7.1 to 13.1) | 12.1 (8.2 to 16.8) | <0.001 | |||
| ⊿L | −3.5 (−8.0 to 1.2) | −5.0 (−11.8 to 3.5) | 0.307 | |||
| ⊿a | 5.3 (1.8 to 8.0) | 6.2 (3.6 to 8.4) | 0.139 | |||
| ⊿b | 1.4 (0.4 to 3.4) | 1.3 (−0.4 to 2.8) | 0.075 | |||
| LCI | ||||||
| ⊿E | 13.8 (10.5 to 16.3) | 11.9 (10.2 to 15.8) | 0.132 | |||
| ⊿L | 1.0 (−3.4 to 4.6) | 0.9 (−2.8 to 4.7) | ||||
| ⊿a | 2.7 (−3.5 to 10.6) | 2.4 (−3.3 to 7.6) | ||||
| ⊿b | 7.7 (4.9 to 12.6) | 8.0 (5.3 to 12.4) | ||||
| Morphology | ||||||
| White Light Images ⊿E | ||||||
| Elevated (n=17) | 7.2 (5.7 to 9.0) | |||||
| Flat (n=8) | 4.8 (4.2 to 8.5) | |||||
| Depressed (n=15) | 6.8 (4.9 to 9.7) | |||||
| Color enhancement | C1 | C2 | ||||
| BLI-bright ⊿E | ||||||
| Elevated (n=17) | 10.5 (7.7 to 13.2) | 11.0 (7.1 to 15.1) | 0.149 | |||
| Flat (n=8) | 6.5 (4.9 to 10.0) | 8.2 (6.4 to 11.5) | 0.012 | |||
| Depressed (n=15) | 8.9 (6.2 to 13.0) | 9.9 (7.2 to 12.9) | 0.91 | |||
| BLI ⊿E | ||||||
| Elevated (n=17) | 8.6 (5.9 to 12.6) | 12.1 (8.2 to 16.6) | 0.002 | |||
| Flat (n=8) | 10.1 (6.3 to 12.0) | 10.0 (7.7 to 14.3) | 0.093 | |||
| Depressed (n=15) | 10.5 (8.1 to 13.9) | 11.5 (8.3 to 16.6) | 0.017 | |||
| LCI ⊿E | ||||||
| Elevated (n=17) | 12.9 (9.6 to 17.0) | 11.8 (9.6 to 15.8) | 0.723 | |||
| Flat (n=8) | 11.5 (8.3 to 15.4) | 10.3 (7.6 to 12.3) | 0.124 | |||
| Depressed (n=15) | 14.1 (10.6 to 16.4) | 13.4 (10.2 to 16.7) | 0.91 | |||
| Rate of pathological circumferential intestinal metaplasia | C1 | C2 | ||||
| >75% (n=30) | ||||||
| BLI-bright ⊿E | 8.9 (6.0 to 12.5) | 9.9 (7.1 to 11.6) | 0.079 | |||
| BLI ⊿E | 8.4 (6.4 to 12.3) | 11.1 (8.2 to 15.0) | <0.001 | |||
| ≤75% (n=10) | ||||||
| BLI-bright ⊿E | 13.5 (10.0 to 14.4) | 14.6 (11.8 to 17.0) | 0.263 | |||
| BLI ⊿E | 12.2 (9.9 to 15.5) | 14.8 (9.3 to 18.7) | 0.028 | |||
| >50% (n=35) | ||||||
| BLI-bright ⊿E | 9.0 (6.2 to 12.6) | 10.5 (7.2 to 13.7) | 0.019 | |||
| BLI ⊿E | 9.7 (7.0 to 12.3) | 11.5 (8.3 to 15.4) | <0.001 | |||
| ≤50% (n=5) | ||||||
| BLI-bright ⊿E | 14.1 (13.9 to 15.9) | 15.4 (4.2 to 18.1) | 0.893 | |||
| BLI ⊿E | 13.5 (5.3 to 15.7) | 18.6 (6.7 to 18.7) | 0.043 | |||
| Helicobacter pylori status | C1 | C2 | ||||
| Negative (n=5) | ||||||
| BLI-bright ⊿E | 12.5 (6.6 to 14.2) | 8.3 (7.2 to 15.1) | 0.502 | |||
| BLI ⊿E | 8.0 (7.2 to 13.1) | 8.0 (8.0 to 16.7) | 0.08 | |||
| Positive (n=12)* | ||||||
| BLI-bright ⊿E | 10.5 (8.5 to 12.8) | 10.9 (9.5 to 13.5) | 0.53 | |||
| BLI ⊿E | 8.4 (7.8 to 10.9) | 9.5 (8.3 to 12.9) | 0.028 | |||
Data are shown as median (1st quartile–3rd quartile).
⊿E* shows the color difference and is calculated using the following formula: [(⊿L*)2+(⊿a*)2+(⊿b*)2]1/2. L* is defined as lightness, a* is the red-green component, and b* is the yellow-blue component. ⊿L is obtained from the formula: (absolute L of malignant lesion − absolute L of surrounding mucosa) × 100/255. Values (⊿a, ⊿b) were obtained by subtracting the value for the surrounding mucosa from the value for the malignant lesion. WLI = white light imaging; BLI = blue laser imaging; LCI = linked color imaging. *Two double cancers were included.