Table 1.

Influence of Adequate Initial Antibiotic Therapy on Mortality Rate in Ventilator-Associated Pneumonia

Series	Year	No. of patients	Adequate treatment death/pts (%)	Inadequate treatment death/pts (%)	p
Celis et al. [10]	1988	118	33/118 (28)	11/12 (92)	<0.001
Alvarez-Lerma [3]	1996	430	46/284 (16)	36/146 (25)	0.03
Luna et al. [5]	1997	50	6/16 (38)	31/34 (91)	<0.01
Rello et al. [6]	1997	113	13/86 (15)	10/27 (37)	<0.05
Sanchez-Nieto et al. [22]	1998	38	6/24 (25)	6/14 (43)	NS
Kollef et al. [4]	1999	411	48/106 (45)	51/305 (17)	<0.01
Bercault & Boulain [14]	2001	135	37/92 (40)	18/34 (53)	NS
Dupont et al. [16]	2001	111	21/55 (38)	27/57 (47)	NS
Iregui et al. [19]	2002	107	21/74 (28)	23/33 (70)	<0.01
Hanes et al. [18]	2002	163	9/79 (11)	21/84 (25)	0.02
Dupont et al. [17]	2003	322	37/220 (17)	21/92 (23)	NS
Leroy et al. [20]	2003	132	42/106 (40)	16/26 (62)	0.04
Clec'h C et al. [15]	2004	70	2/27 (7)	16/43 (37)	<0.01
Mueller et al. [21]	2005	82	1/28 (4)	12/54 (22)	<0.01
Kollef et al. [12]	2008	76	8/59 (14)	11/17 (65)	<0.01
Rello et al. [11]	2011	484	(35)	(48)	0.01
Tseng et al. [13]	2012	131	20/71 (28)	37/60 (62)	0.0225

NS = non-significant.