Fig. 2. The expression of chemokine ligand (CCL) 11 and serpine F1/pigment epithelium-derived factor (SERPINF1/PEDF) in the mice lungs. PHMG enhances mRNA expressions of (A) CCL11, (B) CCL17 and (C) interleukin (IL)-4 in the mouse lung tissue. (D) Western blotting analysis shows increased expressions of SERPINF1 and β-actin in the lung tissue.

Con, control; OVA, ovalbumin; P/S/CON, control group exposed to PHMG during sensitization; P/S/OVA, OVA group exposed to PHMG during sensitization; IL, interleukin; PHMG, polyhexamethyleneguanidine; BHR, bronchial hyperresponsiveness.

Significance was determined using one-way analysis of variance, ^*P < 0.05, ^†P < 0.01, ^‡P < 0.001.