Table 2. Asthma outcomes according to age and Treg function.
| Asthma outcomes | Asthma | P value | |||||
|---|---|---|---|---|---|---|---|
| AL (n = 8) | AH (n = 8) | YL (n = 10) | YH (n = 6) | AL vs. AH | YL vs. YH | ||
| ACT score | 18.2 ± 6.36 | 13.4 ± 4.24 | 17.0 ± 3.46 | 21.3 ± 1.86 | 0.10 | 0.01 | |
| History of intubation ever | 0 (0.00) | 2.00 (28.6) | 1 (10.0) | 1 (16.7) | 0.20 | 1 | |
| Outcomes in past 12 months: | |||||||
| No. ER visits/patient | 1.12 ± 2.47 | 1 ± 1.29 | 1.80 ± 1.75 | 0.17 ± 0.41 | 0.90 | 0.02 | |
| No. Hospitalizations/patient | 0.50 ± 1.41 | 0.29 ± 0.76 | 0.40 ± 0.70 | 0 ± 0.00 | 0.72 | 0.10 | |
| No. Urgent care visits/patient | 0.88 ± 1.46 | 3 ± 3.79 | 2.30 ± 1.95 | 0.17 ± 0.41 | 0.20 | 0.01 | |
| No. Patients on oral/IV CS | 5 (62.5) | 5 (71.4) | 9 (90.0) | 3 (50.0) | 1 | 0.12 | |
Data are presented in absolute numbers (%) or mean ± standard deviation. Bold-faced values are significant.
Treg, T regulatory cell; AL, aged low-T regulatory cell; AH, aged high-T regulatory cell; YL, younger low-T regulatory cell; YH, younger high-ET regulatory cell; ACT, Asthma Control Test; ER, emergency room; CS, corticosteroids; IV, intravenous.