Table 3. Treg frequencies and peripheral function of subjects with asthma and controls.
| Inflammatory outcomes | AsA (n = 16) | AsY (n = 16) | CA (n = 14) | CY (n = 15) | P value | ||||
|---|---|---|---|---|---|---|---|---|---|
| AsA vs. AsY | AsA vs. CA | CA vs. CY | AsY vs. CY | ||||||
| Sputum Tregs, % Foxp3+, CD127low | 7.49 (5.51–18.1) | 7.20 (5.16–14.4) | 13.7 (7.69–16.6) | 18.3 (15.4–24.0) | 0.79 | 0.69 | 0.06 | 0.03 | |
| Peripheral Tregs, % Foxp3+, CD127low | 6.41 (3.97–10.6) | 6.92 (4.94–13.8) | 7.81 (3.3–16.8) | 5.25 (3.03–10.5) | 0.95 | 0.74 | 0.62 | 0.66 | |
| Peripheral Treg function, AUC | |||||||||
| AUC | 21.9 ± 22.3 | 25.3 ± 30.0 | 8.5 ± 7.7 | 17.4 ± 16.1 | 0.72 | 0.04 | 0.07 | 0.37 | |
Data are presented in means ± standard deviation or median (interquartile range). Bold-faced values are significant.
AsA, aged subjects with asthma; AsY, younger subjects with asthma; CA, aged subject in control; CY, younger subjects in control; AUC, area under curve.