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. 2021 Apr 1;39(3):470–488. doi: 10.5534/wjmh.210025

Table 3. Indications for AOX therapy.

SN Indications for AOX therapy Self-reported responses
A (n=1,260) Prescription of the antioxidants for the treatment of male infertility
No, I never do so 182 (14.4)
Yes, but only for specific groups of patients 528 (41.9)
Yes, I routinely do so 550 (43.7)
Total 1,260 (100)
B (n=1,039) Clinical conditions treated
Risk factors for oxidative stress (obesity, age, smoking) 707 (68.0)
Idiopathic oligoasthenoteratozoospermia 659 (63.4)
Unexplained infertility 651 (62.6)
Isolated asthenozoospermia 629 (60.5)
Isolated teratozoospermia 501 (48.2)
Isolated oligozoospermia 479 (46.1)
Varicocele 429 (41.3)
Increased SDF 377 (36.3)
Empirically before assisted conception 536 (51.6)
Necrozoospermia 287 (27.6)
Azoospermia 166 (16.0)
Other 11 (1.1)
Altered seminal oxidative stress markers 7 (0.7)
Genital tract infection/inflammation 7 (0.7)
C (n=1,039) Duration of antioxidant treatment (mo)
<3 83 (8.0)
3 454 (43.7)
3–6 401 (38.6)
6–9 27 (2.6)
Indefinitely, until achieving conception 74 (7.1)

Values are presented as number (%).

(A) Prescription of AOX in clinical management of male infertility, (B) clinical conditions treated (percentage calculated based on the total number of participants answering this multiple option question), and (C) duration of treatment.

SN: serial number, AOX: antioxidant, SDF: sperm DNA fragmentation.