Fig. 1. Effect of two-month administration to wild type rabbits of a gonadotrophin-releasing hormone (GnRH) analogue (leuroplide) with or without testosterone (T) administration on biological and experimental parameters, including circulating T (A), visceral fat accumulation (B), prostate-specific antigen (PSA) gene expression within the prostate (D), and in vitro penile responsiveness to a maximal (3 µM) acetylcholine (Ach) concentration (C), expressed as area under the curve. Untreated rabbit were used as a control. Results are derived from data from previous studies [23,24,25,26] and from unpublished observations. RD: regular diet, VAT: visceral adipose tissue.