Fig. 4. Effect of two-month administration to wild type rabbits of a gonadotrophin-releasing hormone (GnRH) analogue (leuroplide) with or without testosterone (T) administration on gene expression in liver homogenates. In particular, this graphs show effects on (A) TIMP metallopeptidase inhibitor 1, (B) endothelin receptor A (ETA), (C) endothelin receptor B (ETB), and (D) Rho associated coiled-coil containing protein kinase 2 (ROCK2). Untreated rabbit were used as a control. Results are derived from data from previous studies [23,24,25,26] and from unpublished observations. RD: regular diet.