Table 6.
Static and dynamic “true* EUGR” compared with “true* non-EUGR” and their comorbidities for INTERGROWTH-21st and Fenton 2013.
| Static true EUGR | Dynamic true EUGR | |||
|---|---|---|---|---|
| IW-21 | Fenton | IW-21 | Fenton | |
| N = 147 (35.7) | N = 243 (60.4) | N = 163 (39.6) | N = 212 (52.7) | |
| Male sex | 86 (58.5) | 129 (53.1) | 97 (59.5) | 114 (53.8) |
| Gestational age (weeks) | 28.76 ± 2.20 | 29.08 ± 2.1 | 28.21 ± 1.99 | 28.38 ± 1.96 |
| Birth weight (g) | 1,104 ± 236 | 1,144 ± 232 | 1,118.6 ± 230.3 | 1,121.46 ± 225.19 |
| z-score BMI at birth | −0.56 ± 0.84 | −0.42 ± 1.02 | −0.08 ± 0.9 | −0.15 ± 0.94 |
| z-score BMI at discharge | −1.18 ± 0.87 | −1.06 ± 0.69 | −1.1 ± 0.76 | −1.03 ± 0.75 |
| Length of stay (days) | 78.7 ± 34.3 | 69.3 ± 28.9 | 79.37 ± 31.59 | 74.46 ± 28.03 |
| Intubation resuscitation | 80 (54.4) | 117 (48.1) | 103 (63.2) | 123 (58) |
| RDS | 106 (72.1) | 171 (70.4) | 132 (81) | 163 (76.9) |
| MV | 117 (79.6) | 178 (73.3) | 144 (88.3) | 177 (83.5) |
| Early-onset sepsis | 7 (4.8) | 14 (5.8) | 10 (6.1) | 11 (5.2) |
| Late-onset sepsis | 71 (48.3) | 102 (42) | 74 (45.5) | 91 (42.9) |
| Anemia (transfusion) | 72 (59.5) | 92 (45.8) | 79 (59.8) | 95 (54.3) |
| NEC | 10 (6.8) | 14 (5.8) | 13 (8) | 13 (6.1) |
| PDA | 59 (40.1) | 84 (34.6) | 75 (46) | 82 (38.7) |
| Hypotension (inotropic support) | 19 (12.9) | 24 (9.9) | 23 (14.1) | 22 (10.4) |
| Acute kidney injury | 8 (6.7) | 6 (3) | 6 (4.5) | 5 (2.9) |
| Parenteral nutrition at 28 days | 24 (16.4) | 30 (12.4) | 33 (20.4) | 36 (17.1) |
| ROP ≥ stage 2 | 30 (20.8) | 34 (14.6) | 32 (19.8) | 39 (18.7) |
| BPD | 53 (36.1) | 75 (30.9) | 66 (40.5) | 78 (36.8) |
| PVL | 16 (10.9) | 23 (9.5) | 22 (13.5) | 25 (11.8) |
| HIV grade 3–4 | 12 (8.2) | 14 (5.8) | 16 (9.8) | 17 (8) |
Values are expressed as number (%) or mean ± standard deviation.
IW-21, INTERGROWTH-21st; Fenton, Fenton 2013. BMI, body mass index; EUGR, extrauterine growth restriction; RDS, respiratory distress syndrome; MV, mechanical ventilation; NEC, necrotizing enterocolitis; PDA, patent ductus arteriosus; ROP, retinopathy of prematurity; BPD, bronchopulmonary dysplasia; PVL, periventricular leukomalacia; HIV, intraventricular hemorrhage.
*
True EUGR excludes IUGR (denominator IW-21 and Fenton are n = 412 and n = 402 respectively).