Table 3.
Drug | Disease & parasite | Regimen | Efficacy | Remark | References |
---|---|---|---|---|---|
Albendazole | Neurocysticercosis (metacestode of Taenia solium) | 15 mg/kg/day×7–15 days | Effective | Parenchymal, subarachnoid, and ventricular cysticerci Combined with steroids | [22,158,159] |
Cutaneous cysticercosis (metacestode of Taenia solium) | 15 mg/kg/day×28 days | Satisfactory | Combined with steroids | [163] | |
Cystic echinococcosis (hydatid of Echinococcus granulosus) | 400 mg b.i.d.×3–6 months with 14 days of break | Fairly good | Combined with PAIRa | [174] | |
Alveolar echinococcosis (hydatid of Echinococcus multilocularis) | 400 mg b.i.d.×2–3 years with 14 days of break | Fairly good | Minimum 2–3 years, but probably lifelong | [174] | |
| |||||
Mebendazole | Neurocysticercosis (metacestode of Taenia solium) | Mebendazole plus praziquantel recommended | - | - | [164] |
Cutaneous cysticercosis (metacestode of Taenia solium) | Mebendazole plus praziquantel recommended | [164] | |||
Cystic echinococcosis (hydatid of Echinococcus granulosus) | 50–70 mg/kg/day× 6–24 months | Fairly good | Lower efficacy than albendazole | [172,186] | |
Alveolar echinococcosis (hydatid of Echinococcus multilocularis) | 45–48 mg/kg/day×13 years | Seemingly good | May be parasiticidal | [189] |
PAIR consists of puncture, aspiration, injection of scolicidal agent, and reaspiration.