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. 2021 Jun 21;9:685873. doi: 10.3389/fcell.2021.685873

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Copyright © 2021 Zhang, Yan, Liu, Chen, Li, Tang, Li, Duan and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hAFSC-exo suppress myofibroblast aggregation on wound healing in rats. (A) IF staining of α-SMA and collagen I in the healed tissues (scale bar = 300 μm). (B–I) mRNA levels of α-SMA, Col1a2, Col3a1, TGF-β1, TGF-β3, MMP1, MMP3, and TIMP1 in the healed tissues. *P < 0.05; **P < 0.01; ***P < 0.001; mean ± SD; n = 5. α-SMA, α-Smooth muscle actin; MMP1, matrix metalloproteinase 1; MMP3, matrix metalloproteinase 3; TGF-β1, transforming growth factor-β1; TGF-β3, transforming growth factor-β3; TIMP1, tissue Inhibitor of metalloproteinases 1.