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. 2021 Jun 21;9:685873. doi: 10.3389/fcell.2021.685873

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Copyright © 2021 Zhang, Yan, Liu, Chen, Li, Tang, Li, Duan and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hAFSC-exo improves regeneration and suppresses fibrotic scarring by inhibiting the TGF-β signaling pathway. Let-7-5p, miR-22-3p, miR-27a-3p, miR-21-5p, and miR-23a-3p carried by hAFSC-exo may inhibit myofibroblast formation by down-regulating the expression of TGF-βR1 and TGF-βR2 in the TGF-β signaling pathway.