Fig. 2.

DGE analysis between SSNS or SRNS and control identified significant genes and pathways. (A) Venn diagram indicating 55 genes (40%) of total DEG common to SSNS and SRNS. (B) Nephrotic plasma induced DEG network: The green boxes represent pathways and the red hexagons represent the significant DEGs in the respective pathways. Node size corresponds to the centrality of a particular network. Tumor necrosis factor is involved in multiple pathways such as transforming growth factor-beta signaling, cytokine and inflammatory, osteoclast differentiation, and mitogen-activated protein kinase signaling pathway. SOCS3 is another significant gene involved in the osteoclast differentiation pathway, cytokine signaling, the immune system, and type II diabetes. DGE, differential gene expression; DEGs, differentially expressed genes; SRNS, steroid-resistant nephrotic syndrome; SSNS, steroid-susceptible nephrotic syndrome.