Table 1.
Subject ID | Sex | Age at onset | Age at sampling | Diagnosis at sampling | Immunosuppressant prior to*, at sampling†, at follow-up‡ | Biopsy findings | Renal status at sampling | Status at last follow-up |
---|---|---|---|---|---|---|---|---|
Control 1 | Male | N/A | 27 | N/A | N/A | N/A | Normal | N/A |
Control 2 | Female | N/A | 28 | N/A | N/A | N/A | Normal | N/A |
SRNS 1 | Male | 2 yr 10 mo | 3 yr | SRNS | Steroids*, cyclophosphamide‡, tacrolimus‡ | MCD | 3+ | Good response to tacrolimus with urine albumin 1+ |
SRNS 2 | Male | 2 yr 3 mo | 2 yr 6 mo | SRNS | Steroids*, tacrolimus‡ | Medulary tissue – result unknown IgM negative | 4+ | No response to tacrolimus, progressed to ESRD |
SSNS 1 | Female | 5 yr 7 mo | 9 yr | FRNS | Steroids*, levamisole†, cyclophosphamide‡, tacrolimus‡ | Messengial hypercellularity | 4+ | Poor response to levamisole and cyclophosphamide, responds to tacrolimus |
SSNS 2 | Male | 2 yr 6 mo | 3 yr 2 mo | IFRNS | Steroids* | MCD | 4+ | Continues to remain IFRNS |
SSNS 3 | Female | 13 yr | 13 yr | IFRNS | Steroids* | Biopsy not done during sampling | 3+ | Has changed course to SDNS |
SSNS 4 | Male | 2 yr | 6 yr | FRNS | Levamisole | Not done | 4+ | Good response to levamisole |
Medicine given prior to sampling,
Medicine at sampling,
Medicine at follow-up.
N/A, not applicable; SRNS, steroid-resistant nephrotic syndrome; Ig, immunoglobulin; MCD, minimal-change disease; ESRD, end-stage renal disease; FRNS, frequent relapse nephrotic syndrome; IFRNS, infrequent relapse nephrotic syndrome; SDNS, steroid-dependent nephrotic syndrome.