Table 2.
Pathway analysis of DEGs within disease groups (SSNS or SRNS vs. control)
| Pathway | Mapped DEGs | Entrez gene ID | Fold change in SSNS against control | Fold change in SRNS against control | Specificity factor for kidney (Enrichnet) |
|---|---|---|---|---|---|
| TGF-beta signaling pathway | ID3 | 3399 | 1.99 | 1.26 | 8.94 |
| ID1 | 3397 | 1.96 | 1.87 | ||
| TNF | 7124 | 1.33 | 0.47 | ||
| SMAD7 | 4092 | 1.2 | 1.36 | ||
| GDF6 | 392255 | -0.01 | 1.29 | ||
| JAK-STAT pathway | CSF3 | 2354 | 0.57 | 0.68 | 4.44 |
| CLCF1 | 2353 | 1.15 | 0.91 | ||
| IL11 | 9021 | 1.33 | 1.92 | ||
| SOCS3 | 3726 | 1.94 | 1.35 | ||
| Osteoclast differentiation | FOS B | 1843 | 3.21 | 2.76 | - |
| FOS | 776 | 1.99 | 1.1 | ||
| SOCS3 | 4616 | 1.94 | 1.35 | ||
| JUNB | 1649 | 1.23 | 1.59 | ||
| Cytokine-cytokine receptor interaction | IL11 | 1847 | 1.33 | 1.92 | 1.74 |
| CXCL2 | 23529 | 1.19 | 0.31 | ||
| CSF3 | 3589 | 0.57 | 0.68 | ||
| CXCR7 | 9290 | 0.5 | 1 | ||
| MAPK signaling pathway | DUSP1 | 1440 | 1.69 | 1.65 | -0.06 |
| CACNA1D | 57007 | 1.66 | 0.08 | ||
| GADD45B | 4616 | 1.44 | 1.81 | ||
| DDIT3 | 1649 | 1.43 | 0.84 | ||
| DUSP5 | 1847 | 1.3 | 1.41 | ||
| CLCF1 | 23539 | 1.15 | 0.91 |
DEG, differentially expressed genes; SSNS, steroid-susceptible nephrotic syndrome; SRNS, steroid-resistant nephrotic syndrome; TGF, transforming growth factor; JAK-STAT, Janus kinase-signal transducer and activator of transcription; MAPK, mitogen-activated protein kinase.