Table 2a.
All adverse events
| Patient ID | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | |||
| Adverse Event (AE) | AE Grade | Number of assessments with AE | ||||||||||||
| Hematology | Anemia | 1 | 11 | 11 | 3 | 8 | 2 | 6 | 7 | 10 | 3 | 11 | 0 | 0 |
| Leukopenia | 1 | 4 | 0 | 7 | 0 | 0 | 7 | 0 | 0 | 0 | 6 | 0 | 0 | |
| Thrombocytopenia | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 6 | 0 | |
| Renal | Electrolyte levels | 1 | 3 | 2 | 0 | 9 | 3 | 8 | 0 | 0 | 11 | 0 | 3 | 0 |
| Creatinine level | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 0 | 0 | 0 | |
| Hepatic | Elevated ALT/AST | 1 | 2 | 0 | 8 | 0 | 0 | 0 | 7 | 0 | 0 | 0 | 0 | 0 |
| Elevated ALP | 1 | 0 | 0 | 0 | 0 | 0 | 7 | 11 | 1 | 11 | 0 | 0 | 0 | |
| Elevated ALP | 2 | 0 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Cardiac | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Clinical AE | 1 | 0 | 4 | 3 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | |
Patients were assessed for adverse events (clinical and hematological/biochemical) over 11 time points