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. 2021 Mar 2;12(2):465–487. doi: 10.1016/j.jcmgh.2021.02.010

Figure 8.

Figure 8

Incapable IFN-γ-IFNGR1 signaling accounts for paraspeckle mediated-adoptive T-cell therapy resistance. (A) Schematic diagram of animal experimental protocols to assess effects of blocking IFNGR1 with anti-IFNGR1 mAb on adoptive T-cell anti-tumor immunity in immunodeficient RAG-/- mouse (n = 6). Tumor growth curve of human HCC-bearing mice. (B) Image showing comparison of excised tumor size of HCC xenografts in RAG1-/- mice. (C) Schematic diagram of animal experimental protocols to assess effects of neutralizing IFN-γ with anti-IFN-γ mAb on adoptive T-cell anti-tumor immunity in immunodeficient RAG-/- mouse (n = 6). Tumor growth curve of human HCC-bearing mice. (D) Image showing comparison of excised tumor size of HCC xenografts in RAG1-/- mice. Data are represented as means ± SD (n = 6; ∗P < .05, ∗∗P < .01).