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. 2021 May 19;3(7):531–540. doi: 10.1096/fba.2020-00066

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© 2021 The Authors. FASEB BioAdvances published by the Federation of American Societies for Experimental Biology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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spE15 peptide “GLLLPH” is present also in myotubulin‐related protein‐12 isoform 2 protein (MTMR12). A, Amino acid alignment between splice Klotho isoform 15 AA sequence and MTMR12. B, Immunoblot for WT mouse brain lysate for anti‐spE15, and anti‐MTMR12 (left panel) and immunoprecipitation followed by immunoblot for spE15 and MTMR12 (right panel). In both MTMR12 immunoblots we detect a band nearing 75 kDa, and this same band appears in the IB for anti‐spE15. C. Immunohistochemistry on mouse WT brain sections using anti‐spE15 (left panel) and anti‐MTMR12 (right panel). CP: Choroid plexus; EC: Ependymal cells; MGE: medial ganglionic eminence. The anti‐spE15 stains in the choroid Plexus (CP) and the Ependymal cells (EC), while the MTMR12 stains in the Medial ganglionic eminence (MGE)