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. 2021 Jun 21;12:680040. doi: 10.3389/fneur.2021.680040

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Copyright © 2021 Song, Dornbos, Lan, Jiao, Wan, Guo, Ding, Yang, Ji and Meng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The pathophysiology of hemorrhagic transformation associated with CCVT (A–C) and follow-up of non-enhanced (D–F) and contrast-enhanced (G–I) HR-MRBTI of the brain in Case 2 (on admission, D,G; 2-week follow-up, E,H; 6-week follow-up, F,I). The orange asterisk represents CVSS, and the orange arrow indicates CCVT. Initially, CCVT was accompanied by surrounding edema (A,D,G); but hemorrhagic transformation would likely arise if standard anticoagulation and hydration therapy were not administered appropriately (B,E,H). Parenchymal edema and the hematoma were gradually absorbed, and the lesion underwent neural recovery (C,F,I).