Fig. 1.

Systemic IgG responses after nasal DNA/protein vaccination with or without Invaplex. ELISA was used to measure concentrations of serum IgG antibodies to SIV Env protein immunogen (left panel) and SIV Gag,Pol antigens (right panel) encoded by the DNA vaccine. Shown are geometric means with SEM. Black arrows indicate when immunizations with DNA/protein ± Invaplex_NAT were performed. The red arrow indicates when Ad-SIV boosting was done. Asterisks indicate time points when Gp 3 had significantly greater antibody concentrations than Gp 1 (p ≤ 0.05 by Mann-Whitney). Gp 2 antibody levels did not differ significantly from Gp 1 at any time. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)