TABLE 1.
Receptor specificity of FGFs.
| FGF subfamily | FGF | Cofactor | FGF receptor activity |
|---|---|---|---|
| FGF1 subfamily | FGF1 | Heparin or heparan sulfate | All FGFRs |
| FGF2 | FGFR1c,3c > 2c,1b,4 | ||
| FGF4 subfamily | FGF4 | FGFR1c,2c > 3c,4 | |
| FGF5 | FGFR1c,2c > 3c,4 | ||
| FGF6 | FGFR1c,2c > 3c,4 | ||
| FGF7 subfamily | FGF3 | FGFR2b > 1b | |
| FGF7 | FGFR2b > 1b | ||
| FGF10 | FGFR2b > 1b | ||
| FGF22 | FGFR2b > 1b | ||
| FGF8 subfamily | FGF8 | FGFR3c > 4>2c > 1c >> 3b | |
| FGF17 | FGFR3c > 4>2c > 1c >> 3b | ||
| FGF18 | FGFR3c > 4>2c > 1c >> 3b | ||
| FGF9 subfamily | FGF9 | FGFR3c > 2c > 1c, 3b >> 4 | |
| FGF16 | FGFR3c > 2c > 1c,3b>>4 | ||
| FGF20 | FGFR3c > 2c > 1c,3b>>4 | ||
| FGF19 subfamily | FGF19 | β-Klotho | FGFR1c,2c,3c,4 |
| FGF21 | FGFR1c,3c | ||
| FGF23 | α-Klotho | FGFR1c,2c,3c,4 | |
| FGF11 subfamily | FGF11 | Is not combined with FGFRs | |
| FGF12 | |||
| FGF13 | |||
| FGF14 | |||