TABLE 1A.
Demographic and clinical characteristics of phenotypic differences between DLB patient groups with different clinical onset of symptoms.
| Psych-onset | MCI-onset | Mixed onset | Statistics psych- | Psych- vs. | MCI- vs. | Comparison of | |
| (n = 30) | (n = 15) | (n = 13) | vs. MCI-onset | mixed onset | mixed onset | three groups ANOVA | |
| Demographics | |||||||
| Age years | 74.6 ± 11.5 | 77.1 ± 19.8 | 74.5 ± 20.6 | 0.25 | 0.78 | 0.17# | 0.52 |
| Sex female N, % | 13 (45%) | 3 (20%) | 5 (38%) | 0.28 | 0.72 | 0.41 | 0.31 |
| =1 core clinical feature N, % | 17 (57%) | 7 (47%) | 9 (69%) | 0.54 | 1 | 0.27 | 0.39 |
| >1 core clinical feature N, % | 6 (20%) | 2 (15%) | 5 (33%) | 0.69 | 0.19 | 0.19 | 0.48 |
| Main core clinical features | |||||||
| Fluctuating cognition N, % | 9 (30%) | 2 (13%) | 4 (31%) | 0.28 | 1 | 0.37 | 0.67 |
| REM sleep behavioral disorder N, % | 0 (0%) | 1 (7%) | 0 (0%) | 0.33 | 1 | 1 | 0.22 |
| Repetitive hallucinations N, % | 11 (37%) | 5 (33%) | 6 (46%) | 0.75 | 0.73 | 0.06 | 0.98 |
| Parkinsonism N, % | 18 (60%) | 11 (73%) | 7 (54%) | 0.51 | 0.74 | 0.4 | 0.71 |
| Supportive clinical features | |||||||
| Neuroleptic hypersensitivity N, % | 1 (3%) | 1 (7%) | 2 (15%) | 1 | 0.21 | 0.21 | 0.23 |
| Postural instability N, % | 5 (17%) | 5 (33%) | 3 (23%) | 0.26 | 1 | 0.68 | 0.89 |
| Repeated falls N, % | 3 (10%) | 3 (20%) | 1 (7%) | 0.38 | 1 | 0.65 | 0.68 |
| Syncopes N, % | 0 (0%) | 0 (0%) | 0 (0%) | 1 | 1 | 1 | 1 |
| Severe autonomic dysfunction N, % | 8 (27%) | 1 (7%) | 1 (7%) | 0.23 | 0.23 | 1 | 0.05 |
| Hypersomnia N, % | 0 (0%) | 0 (0%) | 1 (7%) | 1 | 1 | 0.46 | 0.22 |
| Hyposmia N, % | 0 (0%) | 0 (0%) | 2 (15%) | 1 | 1 | 0.48 | 0.2 |
| Hallucinations in other modalities N, % | 3 (10%) | 2 (13%) | 4 (31%) | 1 | 0.67 | 0.05 | 0.33 |
| Delusions N, % | 11 (37%) | 1 (7%) | 5 (38%) | 0.04* | 1 | 0.08 | 0.08 |
| Apathy N, % | 2 (7%) | 1 (7%) | 1 (7%) | 1 | 1 | 1 | 0.96 |
| Anxiety N, % | 14 (47%) | 1 (7%) | 5 (38%) | 0.02* | 0.74 | 0.06 | 0.02 |
| Depression N, % | 20 (67%) | 4 (27%) | 5 (38%) | 0.03* | 0.1 | 0.68 | 0.03 |
| Supportive biomarker | |||||||
| Temporal preservation N, % | 6 (20%) | 3 (20%) | 4 (31%) | 1 | 0.45 | 0.67 | 0.66 |
| EEG slowing posterior N, % | 1 (3%) | 2 (13%) | 0 (0%) | 0.67 | 0.25 | 1 | 0.12 |
EEG, electroencephalography, DLB, Dementia with Lewy bodies, MCI, mild cognitive impairment, MCI-onset, mild cognitive impairment onset of symptoms, N, Number, Psych-onset, psychiatric symptom onset, REM, rapid eye movement, SEM, standard error of the mean. Statistics: Fisher’s exact test: *p < 0.05. For comparing age groups a Mann Whitney U test was applied, #a student’s test was applied.