Fig. 2.

Select viral metagenomic contigs encoding C5-MT, TET/JBP, and GT genes. A genome accession number and a contig number assignment are shown to the left of each contig. A more detailed description of the accession numbering system and database sources is located in SI Appendix, Table S1 and SI Materials and Methods. Color assignments of gene predictions are as follows: C5-MT in brown, TET/JBP in cyan, GT in orange, epimerase in yellow, redoxin in red, DNA polymerase in fluorescent green, CTP transferase in dark green, polyamine aminopropyltransferase (PAPT) in light green, and 3-dehydroquinate synthase-like (DHQS) in dark blue. Genes that are colored beige correspond to phage regulatory proteins. Gray genes are proteins of unknown function. The red asterisk marks contig 43, whose C5-MT, TET/JBP, GT-I, and GT-II genes, were expressed and functionally tested both in vivo and in vitro.