Table 5.
Characteristics of adverse reactions related to TB medication by different age groups (N = 246)
| 18–44 y | 45–64 y | 65–74 y | 75–83 y | ≥ 84 y | |
|---|---|---|---|---|---|
| Patients who experienced any adverse reactionsa,b | 4 | 11 | 10 | 18 | 18 |
| Patients with adverse reactions due to TB medicationsa | 4 | 11 | 10 | 17 | 15 |
| Multiple adverse reactionsa,c | 0 | 0 | 2 (20.0) | 2 (11.8) | 5 (33.3) |
| Impact of adverse reaction | |||||
| Modest (%) | 3 (75.0) | 6 (54.6) | 6 (60.0) | 11 (64.7) | 11 (73.3) |
| Severe (%) | 1 (25.0) | 5 (45.5) | 4 (40.0) | 6 (35.3) | 4 (26.7) |
| Type of first adverse event | |||||
| GI intolerance (%) | 0 | 0 | 0 | 0 | 0 |
| Hypersensitivity (%) | 0 | 5 (45.5) | 3 (30.0) | 2 (11.8) | 2 (13.3) |
| Liver injury (%) | 4 (100.0) | 5 (45.5) | 5 (50.0) | 9 (52.9) | 8 (53.3) |
| Musculoskeletal (%) | 0 | 0 | 0 | 0 | 0 |
| Otherd (%) | 0 | 0 | 0 | 2 (11.8) | 4 (26.7) |
| Multiple (%) | 0 | 1 (9.1) | 2 (20.0) | 4 (23.5) | 1 (6.7) |
| Drug responsible for first hold | |||||
| Ethambutol (%) | 0 | 1 (9.1) | 2 (20.0) | 4 (23.5) | 3 (20.0) |
| Isoniazid (%) | 1 (25.0) | 0 | 2 (20.0) | 2 (11.8) | 1 (6.7) |
| Pyrazinamide (%)a,b | 2 (50.0) | 5 (45.5) | 1 (10.0) | 1 (5.9) | 1 (6.7) |
| Rifampin (%) | 1 (25.0) | 1 (9.1) | 3 (30.0) | 4 (23.5) | 5 (33.3) |
| Unspecified TB drug (%) | 0 | 4 (36.3) | 2 (20.0) | 6 (35.3) | 3 (20.0) |
| Other TB drug (%) | 0 | 0 | 0 (0.0) | 0 | 2 (13.3) |
| Drug level of certainty | |||||
| Confirmed (%)a,b | 0 | 4 (36.4) | 1 (10.0) | 0 | 0 |
| High (%)a,b | 4 (100.0) | 7 (63.6) | 9 (90.0) | 17 (94.4) | 15 (100) |
GI gastrointestinal, TB tuberculosis
ap-Value < 0.05 comparing those aged < 65 to those ≥ 65 years
bp-Value < 0.05 comparing those aged < 75 to those ≥ 75 years
cp-Value < 0.05 comparing those aged < 84 to those ≥ 84 years
dOther includes hypoglycemia, thrombocytopenia, ocular, renal failure, anemia