Figure 8. Differential regulation of GlyRs, GABA_ARs, and gephyrin at mixed inhibitory synapses.

Left: Inhibitory GlyRs (dark blue), GABA_ARs (light blue), and gephyrin scaffolds (red) are organized in sub‐synaptic domains (SSD) and are aligned with pre‐synaptic release sites (green), forming trans‐synaptic nanocolumns (dotted boxes). Right: Increased network activity differentially affects the numbers of GABA_AR complexes (light blue pentagons) and the phosphorylation status of gephyrin (phospho‐S270 domain, dark red), while GlyRs and total gephyrin levels are largely unaffected.