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. 2021 Jul 5;40:222. doi: 10.1186/s13046-021-02024-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — RBM17 promotes cell proliferation and migration of PTC cells. A-B RBM17 expression in three human PTC cell lines by qRT-PCR and western blot. β-actin acts as control. C-D Overexpression efficiency of RBM17 in K1 cell transfected with pCMV-RBM17 plasmid by qRT-PCR and Western blot with its quantification result. β-actin referred as a control. Negative control (NC) means control group. E-F RBM17 overexpression promotes proliferation and migration of K1 cells by CCK-8 assay and migration assay compare to vector group (NC). Scale bar = 100 μm. G-H Knockdown efficiency of RBM17 in TPC-1 and BCPAP cells transfected with siRNA-RBM17 by qRT-PCR and western blot with its quantification result. β-actin referred as a control. I-J RBM17 knockdown suppresses proliferation and migration of K1 cells by CCK-8 assay and migration assay compare to vector group (NC). Scale bar = 100 μm. K RBM17 expression in tumor (T) is higher than in adjacent tissues (AT) in 91 pairs PTC patients by IHC. Scale bar = 20 μm. Values are triple replicated and displayed in mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001