Table 4.

Proportion (%) new-borns with nTSH >5 mIU/L in heel prick blood by laboratory and calendar year and by age at heel prick sampling and calendar year (both Cochran-Mantel-Haenzel test)

	2007	2008	2009	2010	2011	2012	2013	2014	2015	p-value
Laboratory
Zwolle	0.45	0.67	0.50	0.93	0.73	0.72	0.48	0.62	0.55	0.8723
Tilburg	0.38	0.55	0.71	0.87	0.69	0.96	0.93	0.69	0.78	0.0018
Capelle	0.44	0.63	0.72	0.97	0.80	0.96	0.77	0.69	0.78	0.0450
Bilthoven	0.46	0.50	0.81	0.96	0.78	0.69	0.81	0.91	0.76	0.0157
Amsterdam	1.40	1.59	1.55	2.44	1.41	1.31	0.96	1.14	2.58	0.3723
Age
day 3	0.81	1.13	0.97	1.7	0.62	0.95	0.89	0.99	1.28	0.8156
day 4	0.8	0.9	1.01	1.35	1.09	1.01	1.02	0.91	1.16	0.0681
day 5	0.54	0.7	0.71	0.85	0.67	0.91	0.5	0.78	0.93	0.0529
day 6	0.47	0.55	0.92	1.41	0.65	0.73	0.58	0.5	0.94	0.4966
day 7	0.15	0.76	0.64	1.33	1.02	0.89	0.36	0.77	1.1	0.029