Table 2.
The enriched GO terms of the up and down regulated differentially expressed genes
| GO ID | CATEGORY | GO Name | P Value | FDR B&H | FDR B&Y | Bonferroni | Gene Count | Gene |
|---|---|---|---|---|---|---|---|---|
| Up regulated genes | ||||||||
| GO:0022610 | BP | biological adhesion | 1.32E−13 | 3.37E−10 | 3.08E−09 | 6.75E−10 | 72 | HLA-DQA1, DACT2, CD83, MDK, UBASH3A, ITGBL1, FAP, MFAP4, SERPINE2, NRXN2, COL14A1, CCR7, ALOX15, COL1A1, LAMB4, COL8A2, STAB2, COL16A1, COMP, TBX21, FERMT1, XG, CCDC80, APOA1, PODXL2, ZAP70, HAPLN1, TENM4, SKAP1, CNTNAP2, PDE5A, CARD11, CTNNA2, SLAMF7, ATP1B2, CX3CR1, LRRC15, IDO1, MYOC, SIGLEC8, ISLR, SMOC2, ITGAL, ITGB7, FREM1, PTN, KIRREL3, NTM, GLI2, FBLN7, DPT, NT5E, ECM2, LCK, OMG, OPCML, TGFB2, RASGRP1, CD2, CD3E, THBS4, CD5, CD6, THY1, TIGIT, CD27, CD40LG, ROBO2, GREM1, LY9, HBB, LEF1 |
| GO:0002682 | BP | regulation of immune system process | 2.20E−10 | 2.25E−07 | 2.05E−06 | 1.12E−06 | 72 | IL34, HLA-DQA1, ESR1, TLR7, CD83, IL17D, MDK, UBASH3A, TNFRSF4, PYHIN1, ZBP1, FCER1A, MS4A2, FCER2, FCN1, CCR7, SMPD3, CCL24, SCARA3, ALOX15, COL1A1, IL31RA, TBX21, XG, CXCL14, APOA1, ZAP70, SH2D1B, SKAP1, PDE5A, CARD11, SLAMF7, CTSG, CX3CR1, IDO1, CXCL10, ITGAL, ACE, SIT1, ITGB7, PTN, TBC1D10C, FCRL3, BPI, GLI2, KLRB1, NPPA, CAMK4, LCK, TGFB2, RASGRP1, CD1C, CD1E, CD2, CD3D, CD3E, THBS4, CD3G, CD247, CD5, CD6, THY1, TIGIT, MS4A1, CD27, GPR68, CD40LG, CD48, GREM1, SH2D1A, LEF1, LRRC17 |
| GO:0031012 | CC | extracellular matrix | 1.09E−20 | 2.77E−18 | 1.89E−17 | 5.54E−18 | 52 | MATN2, COL22A1, MDK, COLQ, MFAP4, SERPINE2, HMCN2, AEBP1, FCN1, CMA1, CTHRC1, COL14A1, SCARA3, COL1A1, LAMB4, COL8A2, COL9A1, COL9A2, COL10A1, MXRA5, FMOD, COL16A1, COMP, CCDC80, APOA1, HAPLN1, CTSG, ADAMTSL2, LRRC15, ASPN, MYOC, NDP, SMOC2, FREM1, PTN, SSC5D, SULF1, DPT, NPPA, ADAMTSL1, ECM2, OGN, ITIH5, TGFB2, LEFTY2, EYS, THBS4, P3H2, LTBP2, GREM1, LUM, LRRC17 |
| GO:0009986 | CC | cell surface | 5.07E−17 | 8.61E−15 | 5.86E−14 | 2.58E−14 | 63 | HYAL4, NRG1, HLA-DQA1, CD83, TNFRSF4, ITGBL1, FAP, SERPINE2, FCER1A, MS4A2, FCER2, FCN1, CXCL9, CCR7, IL31RA, SFRP4, STAB2, DUOX2, APOA1, ACKR4, FCRL6, SCUBE2, CNTNAP2, SLAMF7, CTSG, IL2RB, CX3CR1, LRRC15, CXCL10, NDP, ITGAL, ACE, ITGB7, GFRA3, PTN, PROM1, SSC5D, FCRL3, SULF1, MRC2, NTM, CLEC9A, NT5E, TGFB2, LHCGR, CD1C, HHIP, CD1E, CD2, CD3D, CD3E, CD3G, CD5, CD6, THY1, TIGIT, MS4A1, CD27, CD40LG, CD48, ROBO2, GREM1, LY9 |
| GO:0005102 | MF | signaling receptor binding | 1.36E−09 | 5.99E−07 | 4.41E−06 | 1.20E−06 | 73 | IL34, NRG1, HLA-DQA1, ESR1, GDF6, PENK, TAC4, KDM5D, IL17D, MDK, ITGBL1, FAP, SERPINE2, FCER2, NRXN2, FCN1, CLEC11A, UCHL1, AGTR2, CXCL9, NGEF, CTHRC1, C1QTNF2, CCL22, CCL24, CXCL11, COL16A1, COMP, WNT10B, WNT9A, CXCL14, APOA1, FCRL6, GNA14, OASL, RASL11B, LRRC15, CXCL10, ADAM18, MYOC, SYTL2, NDP, ACE, GDNF, ITGB7, GFRA3, PTN, LYPD1, SCG2, NPPA, NPPB, MCHR1, ECM2, CMTM2, ESM1, LCK, OGN, TGFB2, LEFTY2, CD2, CD3E, THBS4, CD3G, THY1, TIGIT, MS4A1, C1QTNF9, CD40LG, LTB, GREM1, SYTL1, LEF1, LGI1 |
| GO:0098772 | MF | molecular function regulator | 3.79E−04 | 1.59E−02 | 1.17E−01 | 3.34E−01 | 58 | IL34, NRG1, ESR1, GDF6, PENK, TAC4, IL17D, MDK, KCNIP1, SERPINE2, MYOZ1, NRXN2, CLEC11A, SCN2B, AGTR2, CXCL9, NGEF, CCL22, CCL24, CXCL11, HTR2B, PI16, SCG5, WNT10B, WNT9A, CXCL14, APOA1, LRRC55, PPP2R2B, ATP1B2, CXCL10, NDP, BIRC7, GDNF, PTN, TBC1D10C, LYPD1, SCG2, NPPA, NPPB, AZIN2, CMTM2, OGN, RGS4, ITIH5, TGFB2, LEFTY2, RASGRP1, THBS4, THY1, CD27, C1QTNF9, CD40LG, RGS17, LTB, GREM1, LEF1, INKA1 |
| Down regulated genes | ||||||||
| GO:0046903 | BP | secretion | 1.07E−11 | 5.64E−08 | 5.16E−07 | 5.64E−08 | 78 | SERPINA3, HK3, SYN3, ACP3, TRPC4, CFTR, CD109, HMOX2, CHI3L1, F5, F8, F13A1, S100A8, S100A9, SAA1, FCER1G, MGST1, PIK3C2A, HP, AGTR1, PLA2G2A, CCR1, FGF10, C1QTNF1, PLA2G4F, FGR, MERTK, SERPINF2, ALOX5, SYT13, IL17RB, CNR1, ALOX15B, FLT3, ANPEP, P2RY12, ANXA3, FPR1, CR1, SLC1A1, SLC2A1, ARG1, ARNTL, SLC11A1, SLC22A16, LGI3, NSG1, ATP2A2, IL10, SIGLEC9, GPR84, NHLRC2, SSTR5, HPSE, KCNB1, IL1R2, PTX3, GLUL, SYN2, BANK1, WNK3, KNG1, CRISPLD2, CACNA1E, CD177, SIGLEC14, EDN1, EDN2, EDNRB, THBS1, RNASE2, CD38, TLR2, SERPINE1, ELANE, STEAP3, IL1RL1, MCEMP1 |
| GO:0006952 | BP | defense response | 1.04E−06 | 1.63E−04 | 1.49E−03 | 5.50E−03 | 65 | SERPINA3, EREG, VSIG4, TMIGD3, CLEC7A, RAET1E, CHI3L1, F8, CD163, S100A8, S100A9, SAA1, FCER1G, HP, HPR, AGTR1, PLA2G2A, CCR1, FGR, SERPINF2, ALOX5, ALOX5AP, IL17RB, CNR1, SELE, ADAMTS4, ANXA3, FPR1, APOB, SAMHD1, CR1, FCN3, AQP4, ARG1, SLC11A1, MARCO, IL10, BCL6, IL18R1, GGT5, IL1R2, PTX3, SIGLEC10, KNG1, CACNA1E, CD177, SOCS3, SIGLEC14, ADAMTS5, LBP, S1PR3, EDN1, EDNRB, FOSL1, THBS1, RNASE2, NAMPT, TLR2, SERPINE1, ELANE, IRAK3, ELF3, IL1RL1, CALCRL, OSMR |
| GO:0031226 | CC | intrinsic component of plasma membrane | 1.74E−10 | 4.55E−08 | 3.11E−07 | 9.10E−08 | 74 | TPO, EREG, OPN4, TRPC4, CFTR, TMIGD3, KCNIP2, CD163, FCER1G, SCN3A, AGTR1, CCR1, C1QTNF1, MERTK, SYT13, IL17RB, CNR1, TRHDE, SELE, LRRC8E, FLT3, SLC4A7, P2RY12, SLC31A2, CR1, LGR5, AQP3, AQP4, SLC1A1, SLC2A1, SLC5A1, MSR1, SLC11A1, SIGLEC7, ART3, SLCO2A1, ATP2A2, MARCO, GABRR2, SIGLEC9, SLCO4A1, GPR84, SSTR2, SSTR5, IL18R1, LAPTM5, GGT5, SLC52A3, LYVE1, KCNA7, KCNB1, KCND3, NECTIN1, KCNK1, KCNK3, KCNS2, ADGRD1, CACNA1E, GPR4, GPR12, SLC38A4, GPR183, GPRC5A, RGR, S1PR3, RHAG, EDNRB, TGFBR3, TLR2, LGR6, CALCRL, OSMR, HAS2, CDH16 |
| GO:0098805 | CC | whole membrane | 1.91E−03 | 4.99E−02 | 3.41E−01 | 9.97E−01 | 51 | EREG, SYN3, ACP3, TRPC4, CFTR, CD109, HMOX2, CD163, FCER1G, MGST1, PLA2G4F, GPAT2, MOG, CNR1, SELE, ANPEP, P2RY12, ANXA3, FPR1, APOB, SCGN, CR1, AQP4, SLC1A1, SLC2A1, ARG1, MSR1, SLC11A1, NSG1, RAB39A, MARCO, SIGLEC9, GPR84, HPSE, LAPTM5, KCND3, SYN2, SLC9A7, WASF1, CD177, SIGLEC14, GRB14, STEAP4, EDNRB, GRIP1, CD38, TLR2, STEAP3, HAS2, SERPINA5, MCEMP1 |
| GO:0038023 | MF | signaling receptor activity | 2.36E−04 | 1.97E−02 | 1.49E−01 | 2.53E−01 | 55 | EREG, OPN4, CLEC7A, FCER1G, FCGR3A, AGTR1, CCR1, ADGRF5, ADGRF4, MERTK, IL17RB, CNR1, SELE, FLT3, MYOT, ANPEP, P2RY12, ANXA3, FPR1, CR1, LGR5, SIGLEC7, MARCO, PALLD, IL10, GABRR2, IL15RA, GPR82, DNER, PAQR5, GPR84, IL20RA, SSTR2, SSTR5, IL18R1, LYVE1, IL1R2, NECTIN1, ADGRD1, GPR4, GPR12, NPTX2, GPR183, GPRC5A, PKHD1L1, RGR, S1PR3, EDNRB, TGFBR3, TLR2, SERPINE1, IL1RL1, LGR6, CALCRL, OSMR |
| GO:0060089 | MF | molecular transducer activity | 4.71E−04 | 2.10E−02 | 1.59E−01 | 5.04E−01 | 58 | EREG, OPN4, CLEC7A, FCER1G, FCGR3A, AGTR1, CCR1, ADGRF5, ADGRF4, MERTK, IL17RB, CNR1, SELE, FLT3, MYOT, ANPEP, P2RY12, ANXA3, FPR1, CR1, LGR5, SIGLEC7, MARCO, PALLD, IL10, GABRR2, IL15RA, GPR82, DNER, PAQR5, GPR84, IL20RA, STOX1, SSTR2, SSTR5, IL18R1, BLM, CDKL5, LYVE1, IL1R2, NECTIN1, ADGRD1, GPR4, GPR12, NPTX2, GPR183, GPRC5A, PKHD1L1, RGR, S1PR3, EDNRB, TGFBR3, TLR2, SERPINE1, IL1RL1, LGR6, CALCRL, OSMR |
Biological Process(BP), Cellular Component(CC) and Molecular Functions (MF)