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. 2021 Jul 4;21:329. doi: 10.1186/s12872-021-02146-8

Table 4.

Topology table for up and down regulated genes

Regulation Node Degree Betweenness Stress Closeness
Up ESR1 1094 0.250896 7.4E+08 0.392769
Up PYHIN1 342 0.054258 1.1E+08 0.339882
Up PPP2R2B 199 0.023115 35,268,762 0.346839
Up LCK 162 0.033618 18,589,354 0.353915
Up TP63 142 0.018577 39,426,608 0.319664
Up CD247 129 0.013832 18,625,274 0.317784
Up PTN 105 0.016638 36,892,166 0.300662
Up APLNR 103 0.016611 40,715,208 0.288093
Up APOA1 100 0.018834 13,935,332 0.315866
Up CENPA 98 0.009846 31,131,318 0.301786
Up SKAP1 97 0.01599 10,109,482 0.313338
Up FSCN1 88 0.010226 9,387,016 0.335367
Up SCN2B 86 0.01089 24,233,242 0.284756
Up TMEM30B 79 0.016411 10,490,230 0.270807
Up FOXS1 79 0.009408 26,398,078 0.293247
Up COL1A1 76 0.010472 9,315,670 0.308098
Up ZAP70 75 0.007096 5,315,196 0.317614
Up UCHL1 74 0.009753 9,381,024 0.331525
Up HBB 72 0.009984 14,209,592 0.304767
Up NRG1 70 0.01151 13,449,066 0.29526
Up LEF1 61 0.007998 18,260,094 0.290744
Up NT5E 60 0.009599 11,470,634 0.301563
Up MDK 59 0.006889 7,533,352 0.305822
Up ISLR 58 0.010139 9,992,806 0.294012
Up FATE1 57 0.011609 9,248,788 0.281581
Up LRRC15 56 0.010069 4,772,792 0.299094
Up MATN2 54 0.004491 9,580,600 0.286792
Up LIPH 54 0.008197 6,873,658 0.282347
Up MYOC 49 0.005138 12,313,276 0.291029
Up SCARA3 49 0.006492 11,494,220 0.290151
Up NPPA 46 0.009502 4,868,574 0.307143
Up CD83 43 0.005149 5,484,906 0.272841
Up COL14A1 41 0.006129 5,699,128 0.292893
Up CTSG 40 0.003821 1,913,996 0.296155
Up SFRP4 40 0.004006 7,876,966 0.282518
Up TRAF3IP3 38 0.006447 4,263,002 0.290602
Up CLEC11A 38 0.005085 3,520,012 0.283596
Up ATP1B4 38 0.005722 2,476,482 0.245939
Up CD3E 37 0.003892 1,537,326 0.297624
Up SH2D1A 37 0.003969 2,117,220 0.308113
Up DDX3Y 37 0.003754 1,632,916 0.32095
Up PRPH 37 0.001871 1,994,266 0.301494
Up BIRC7 35 0.004835 2,567,254 0.28549
Up CARD11 35 0.002249 2,510,852 0.292173
Up RXRG 35 0.002394 7,134,478 0.26225
Up CCL22 34 0.005706 3,916,024 0.281423
Up CD27 33 0.003915 2,076,446 0.294263
Up GZMB 32 0.003277 6,141,522 0.285602
Up THY1 32 0.003561 1,793,684 0.291509
Up CHRNA3 32 0.004247 3,415,720 0.236631
Up LSP1 32 0.003371 5,734,010 0.281836
Up IL2RB 31 0.002351 1,938,172 0.305808
Up HTR2B 30 0.004018 2,165,998 0.27434
Up DLGAP1 29 0.003816 6,072,882 0.277754
Up TRIM17 29 0.002943 5,543,810 0.275137
Up CTNNA2 29 0.003554 3,511,510 0.30254
Up SERPINE2 28 0.002577 3,031,536 0.27426
Up CD1E 28 0.003282 3,419,392 0.255229
Up MRC2 28 0.003395 2,950,548 0.296276
Up C1QTNF2 28 0.003203 2,505,388 0.270147
Up SH2D1B 27 0.001864 1,043,570 0.29028
Up BRINP1 27 0.001516 4,402,948 0.27726
Up PDIA2 27 0.001967 2,895,182 0.286453
Up CHD5 27 0.001918 5,223,636 0.286503
Up FAP 27 0.003531 5,820,086 0.268583
Up IL31RA 26 0.002073 1,606,954 0.263603
Up GAP43 25 0.002745 2,793,268 0.279858
Up CD5 25 0.001695 655,904 0.295861
Up UBASH3A 25 0.001652 1,347,264 0.290951
Up ROBO2 25 0.002959 3,726,616 0.267048
Up ITGB7 24 0.002686 3,351,660 0.276124
Up HTR2A 24 0.002571 2,472,010 0.275833
Up MOXD1 24 0.002391 2,492,756 0.259926
Up ASB18 24 9.77E−04 3,202,162 0.273001
Up CD2 23 0.002221 926,408 0.287954
Up BCL11B 23 8.18E−04 1,888,298 0.28836
Up STAT4 23 0.001786 2,435,506 0.277166
Up NGEF 23 0.001809 1,548,206 0.277636
Up SMPD3 23 0.002518 2,175,774 0.281
Up FZD2 22 0.003673 3,239,390 0.250335
Up DUSP15 22 0.001253 2,474,532 0.284472
Up CD3D 21 0.001725 1,111,132 0.288589
Up SYT17 21 0.002549 2,482,574 0.285802
Up FCGR3B 21 0.002748 1,492,022 0.282286
Up EGR2 21 0.002934 3,438,856 0.266406
Up ZBP1 21 0.001876 2,664,938 0.26006
Up CAMK4 21 0.001773 3,472,134 0.272716
Up DMC1 20 0.002511 4,659,098 0.254277
Up GDNF 20 0.002515 3,274,958 0.244751
Up FCN1 20 0.002571 1,243,380 0.236742
Up LUM 20 0.002276 1,515,870 0.283903
Up GZMA 20 0.001051 3,258,230 0.276498
Up TGFB2 20 0.002259 1,632,566 0.277119
Up SLAMF7 20 0.00211 1,035,482 0.271708
Up MS4A1 20 0.002857 1,169,078 0.288398
Up ETV4 20 0.001747 1,674,080 0.301883
Up GLI2 20 0.001398 2,977,194 0.285902
Up PHLDA1 19 4.37E−04 818,256 0.298194
Up COL8A2 19 0.00147 1,089,762 0.273835
Up GABRD 19 0.002826 2,629,544 0.25748
Up LMF1 19 0.004342 2,024,228 0.265132
Up F2RL2 19 0.001554 790,338 0.282933
Up LYPD1 19 0.003123 3,995,458 0.266276
Up CAPN6 19 0.001415 3,046,736 0.267802
Up SOX8 19 0.003361 2,763,024 0.251306
Up IER3 18 0.001921 3,613,164 0.282982
Up BEX1 18 0.001034 1,286,206 0.273606
Up COLQ 18 0.001173 1,414,826 0.261234
Up NTM 18 0.00284 2,486,684 0.275102
Up RPS4Y1 18 0.001013 1,200,768 0.287713
Up FERMT1 18 0.001713 4,279,868 0.270315
Up RGS17 18 0.002928 3,868,106 0.249895
Up TNNI1 17 0.001349 1,550,004 0.266765
Up MYOZ1 17 0.00128 2,111,156 0.283203
Up KLHDC8A 17 0.001147 7,007,508 0.251036
Up MYL1 17 7.90E−04 1,213,666 0.289945
Up DIO2 16 0.001161 1,959,228 0.279416
Up ITGAL 16 0.001182 1,521,116 0.271527
Up CRABP2 16 4.13E−04 675,182 0.272171
Up HSH2D 16 0.001425 889,856 0.26034
Up CD48 3 0 0 0.265422
Up CD3G 2 0 0 0.23833
Up LY9 2 0 0 0.240141
Up SIT1 2 0 0 0.264221
Up ATP1A4 2 1.16E−04 79,140 0.235049
Up FMOD 2 3.96E−05 20,526 0.240707
Up CCDC80 2 3.58E−05 499,704 0.288908
Up CCR7 2 0 0 0.244312
Up KCNIP1 1 0 0 0.219995
Up CD6 1 0 0 0.22832
Up FCRL3 1 0 0 0.241062
Up SERTAD4 1 0 0 0.257531
Up PRF1 1 0 0 0.222162
Up C1QTNF9 1 0 0 0.226548
Up OPCML 1 0 0 0.215756
Up ESM1 1 0 0 0.213551
Up CD40LG 1 0 0 0.240053
Up S1PR5 1 0 0 0.24224
Up AGTR2 1 0 0 0.259256
Up NPPB 1 0 0 0.211726
Up SCG5 1 0 0 0.238721
Up PDE5A 1 0 0 0.243548
Up RYR3 1 0 0 0.274755
Up RASEF 1 0 0 0.274755
Up PODXL2 1 0 0 0.213106
Up OGN 1 0 0 0.226548
Up PLCH2 1 0 0 0.238721
Up SCG2 1 0 0 0.267704
Up P3H2 1 0 0 0.207132
Up C12orf75 1 0 0 0.217608
Up ACE 1 0 0 0.241159
Up GNA14 1 0 0 0.217608
Up HDC 1 0 0 0.216614
Up CMA1 1 0 0 0.226713
Up CEACAM3 1 0 0 0.265519
Down PCLAF 817 0.135529 4.95E+08 0.365547
Down CFTR 800 0.168404 4.5E+08 0.378823
Down TK1 188 0.034997 43,663,230 0.331089
Down ECT2 164 0.020509 39,431,940 0.325989
Down FKBP5 157 0.028064 15,963,868 0.346288
Down ANLN 153 0.021564 38,168,832 0.325066
Down ATP2A2 148 0.027131 19,656,040 0.363859
Down BCL6 142 0.022279 29,419,916 0.314181
Down TOP2A 132 0.018571 16,838,266 0.361426
Down ZBTB16 132 0.025165 14,500,206 0.349976
Down S100A9 124 0.01355 11,186,464 0.352219
Down CEP55 123 0.019583 21,505,878 0.316891
Down BLM 108 0.014259 18,458,556 0.321945
Down AGTR1 100 0.019518 14,083,216 0.313564
Down SAMHD1 94 0.011463 12,340,270 0.337357
Down S100A8 88 0.011637 8,662,548 0.361486
Down GRAP2 86 0.011721 16,819,438 0.305936
Down CBS 83 0.011248 20,466,334 0.301591
Down SOCS3 83 0.011071 9,067,820 0.324888
Down GFI1B 80 0.011791 21,469,034 0.299012
Down APOB 78 0.014102 9,290,092 0.319133
Down PCK1 77 0.004102 12,732,476 0.305408
Down MARK3 76 0.008497 19,265,788 0.304512
Down HMOX2 75 0.011098 15,258,770 0.312053
Down PCNT 74 0.011297 9,190,430 0.312261
Down PIK3C2A 69 0.005568 8,768,122 0.313053
Down KIF14 69 0.01035 12,506,564 0.304668
Down WASF1 67 0.009478 18,219,554 0.29633
Down ARNTL 65 0.00974 19,494,854 0.295526
Down ALOX5 65 0.010921 7,343,824 0.306424
Down MCM10 64 0.006773 8,807,396 0.306438
Down THBS1 64 0.008915 6,203,038 0.312694
Down VSIG4 64 0.010353 10,534,518 0.302037
Down WWC1 64 0.007241 14,604,594 0.301647
Down MELK 63 0.008554 18,629,232 0.283953
Down P2RY12 63 0.008962 9,063,088 0.286641
Down PPL 62 0.007851 16,137,388 0.297313
Down MYBL2 59 0.006189 16,766,208 0.291964
Down FAM107A 59 0.006172 12,510,302 0.289688
Down GRIP1 58 0.008069 3,384,760 0.320055
Down ELF3 56 0.004945 7,205,142 0.309118
Down PALLD 55 0.00509 15,467,012 0.293274
Down CTH 54 0.007754 5,179,060 0.296908
Down EIF4EBP1 53 0.005367 9,748,852 0.303946
Down KNG1 53 0.007017 4,204,766 0.304243
Down GLUL 51 0.00728 10,616,752 0.30116
Down SLC2A1 51 0.004557 8,307,646 0.303974
Down HP 51 0.006741 3,398,298 0.314741
Down RPGR 50 0.004441 10,097,488 0.29384
Down TLR2 50 0.00754 8,322,330 0.294595
Down GRB7 49 0.004147 4,832,846 0.308113
Down PPEF1 49 0.001983 3,327,232 0.298276
Down TXNRD1 49 0.00627 2,860,122 0.328561
Down NAMPT 48 0.005035 10,420,710 0.290538
Down BMP7 47 0.007622 4,442,306 0.286981
Down CA14 47 0.005218 4,884,858 0.279189
Down CCR1 46 0.008305 11,217,842 0.27812
Down CDC45 45 0.004479 3,231,162 0.30618
Down ARG1 45 0.004931 2,347,856 0.32381
Down SPC24 43 0.005356 6,589,710 0.294834
Down FGR 43 0.003434 3,020,950 0.303452
Down KIF5C 42 0.004876 2,365,086 0.319586
Down IL1R2 42 0.006825 9,489,620 0.289265
Down SERPINA3 42 0.005518 4,047,110 0.293168
Down DEPDC1B 42 0.002978 9,632,346 0.260838
Down SLC4A7 41 0.006314 2,752,106 0.316232
Down SERPINA5 41 0.003604 13,750,404 0.273206
Down MPP3 40 0.008262 9,328,402 0.297003
Down NCEH1 40 0.009405 3,554,728 0.304214
Down SLC1A1 38 0.008678 2,278,154 0.320573
Down CLSPN 38 0.003668 3,801,300 0.294343
Down BCAT1 38 0.0052 9,066,238 0.269657
Down MYH6 38 0.005049 1,731,786 0.308578
Down IL20RA 37 0.005252 8,769,348 0.267901
Down HOOK1 37 0.005558 7,195,380 0.279177
Down FLT3 37 0.002948 1,938,440 0.292408
Down ADAMTS4 37 0.005524 2,338,476 0.307519
Down CAMSAP3 36 0.003339 4,795,892 0.29578
Down PLA2G2A 35 0.003637 1,686,594 0.300565
Down FOSL1 34 0.004151 10,955,318 0.269402
Down NQO1 34 0.001945 5,351,260 0.289201
Down ELANE 34 0.005024 2,289,646 0.302834
Down KCND3 34 0.002555 9,153,178 0.28203
Down EPN3 34 0.005073 7,423,282 0.280302
Down GPR183 34 0.003642 4,243,792 0.256783
Down CD109 34 0.006381 3,655,940 0.303565
Down TUBA3E 34 0.003459 6,711,886 0.289048
Down TGFBR3 33 0.005143 1,983,082 0.267386
Down NID1 33 0.004536 1,702,236 0.311503
Down STEAP3 33 0.004665 2,788,716 0.285365
Down AMD1 32 0.005714 3,154,782 0.29099
Down EDNRB 31 0.003092 7,273,156 0.265368
Down IL17RB 31 0.004227 6,381,040 0.261527
Down SLC19A2 30 0.004653 2,505,974 0.281302
Down SLC22A16 30 0.004545 3,831,872 0.240618
Down PHACTR3 29 0.002193 6,417,862 0.280976
Down LAPTM5 29 0.003298 2,735,158 0.274317
Down ANGPTL4 29 0.003467 1,447,446 0.325163
Down PPM1E 29 0.002894 5,733,032 0.270427
Down E2F2 28 0.002816 5,508,320 0.28041
Down SERPINE1 28 0.001474 2,497,574 0.271302
Down ACPP 28 0.003084 2,749,550 0.291223
Down KRT7 28 0.002861 1,288,592 0.315774
Down SERPINB8 28 0.002944 3,167,812 0.28186
Down FREM2 28 0.003954 3,395,758 0.276661
Down RNF157 28 0.002172 6,196,626 0.265551
Down PPIP5K2 28 0.003886 8,572,108 0.270014
Down F8 27 0.002839 4,879,016 0.274836
Down TUBAL3 27 0.002055 1,052,840 0.318915
Down ELL2 26 0.003971 6,281,508 0.255859
Down GRB14 25 0.002326 3,092,024 0.28378
Down IRAK3 25 0.00257 6,900,170 0.265897
Down MANEA 25 0.004508 5,075,608 0.263869
Down CLEC7A 25 0.004246 4,293,212 0.277095
Down KLF10 24 0.001607 3,013,994 0.281339
Down GNMT 24 0.00165 3,015,768 0.269136
Down ART3 24 0.002904 2,401,360 0.255748
Down LRRC8E 24 0.003739 4,188,308 0.288665
Down SLA 23 0.001714 1,003,510 0.289329
Down CLEC4G 23 0.002667 2,376,260 0.277495
Down TUBB4A 5 1.28E−04 181,440 0.250652
Down CD38 4 0 0 0.268176
Down FCGR3A 4 1.01E−04 73,756 0.268385
Down F5 3 8.10E−07 708 0.248641
Down EHF 2 7.11E−06 4180 0.254842
Down KIAA1549 2 4.16E−04 193,604 0.261391
Down S100A3 2 1.84E−05 45,822 0.254376
Down ADH1B 2 3.40E−05 28,184 0.233546
Down PAPSS2 2 1.05E−05 8726 0.251868
Down PTX3 1 0 0 0.19143
Down IL15RA 1 0 0 0.234199
Down EDN1 1 0 0 0.209723
Down SERPINF2 1 0 0 0.232451
Down ZNF366 1 0 0 0.282018
Down ACR 1 0 0 0.214588
Down MATN3 1 0 0 0.222881
Down CNR1 1 0 0 0.216205
Down LBP 1 0 0 0.240053
Down ALOX5AP 1 0 0 0.23456
Down SCGN 1 0 0 0.23353
Down MAMDC2 1 0 0 0.248745
Down CDKL5 1 0 0 0.219891
Down CENPM 1 0 0 0.231833
Down KCNIP2 1 0 0 0.219995
Down CPM 1 0 0 0.24533
Down GPSM2 1 0 0 0.245855
Down LSAMP 1 0 0 0.215756
Down KCNK3 1 0 0 0.219353
Down ALOX15B 1 0 0 0.234981
Down ST6GALNAC3 1 0 0 0.233263
Down GPRC5A 1 0 0 0.274755
Down SLC31A2 1 0 0 0.215287
Down MARVELD2 1 0 0 0.218671
Down SNTG2 1 0 0 0.229
Down TRHDE 1 0 0 0.208786
Down SIGLEC7 1 0 0 0.245229
Down SMTNL2 1 0 0 0.265519
Down ANXA3 1 0 0 0.274755
Down F13A1 1 0 0 0.248745
Down ANKRD7 1 0 0 0.233438
Down KCNS2 1 0 0 0.219721
Down SIGLEC9 1 0 0 0.227565
Down SIGLEC10 1 0 0 0.282018
Down C20orf197 1 0 0 0.282018
Down SCGB1D2 1 0 0 0.226548
Down IL1RL1 1 0 0 0.21698
Down PLIN2 1 0 0 0.241935
Down CD163 1 0 0 0.239403
Down HPR 1 0 0 0.240053