Table 1.

Effect of mutated clock genes and the potential diseases in the female reproductive system

Mutated genes	Effect	Potential disease	References
BMAL1	Irregular estrous cycles	POI; PCOS	(55)
	Abnormal StAR expression	POI	(8)
	Insulin resistance	PCOS	(65)
CLOCK	Irregular estrous cycle	POI; PCOS	(28)
	Undetectable LH surges	POI; PCOS	(28)
PER	Excessive androgen	PCOS	(65)
	Irregular estrous cycle	POI; PCOS	(54)
	Lower reproductive rate with fewer litters	POI	(54)
CRY	Reduced oocyte maturation ability	POI; PCOS	(62)
	Irregular estrous cycle	POI; PCOS	(84)
	Infertility	POI; PCOS	(84)