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Activation of PDE2 is essential for mitochondrial Ca2+-mediated CRC cell proliferation in vitro. (A, C, E) MTS assay for cell viability and (B, D, F) EdU incorporation assays for cell proliferation in LS174T cells with treatments as indicated (scale bar, 20 μm). PDE2A, expression vector encoding PDE2A; siPDE2A, siRNA against PDE2A. **P < 0.01.
