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. 2021 Jun 21;11:694941. doi: 10.3389/fonc.2021.694941

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Copyright © 2021 Lin, Ba, Ho, Chen, Cheng, Wang, Xu, Xu, Zhou, Wei, Li and Ling

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IHC staining of the tumor and clinical response in patient 1. (A) Anti-EphA2 IHC staining of tumor tissue before enrollment. (B) Thoracic X-ray performed on days 10, 14, 21, after the infusion of CAR T-cells, showing the development and resolution of pulmonary edema in the right superior and middle lobes. (C) Dynamic changes of critical cytokines in the peripheral blood along with temperature, after the infusion of CAR T-cells. The dotted green line on the x-axis indicating the time window for the use of dexamethasone. (D) Expansion of CAR T-cells in the peripheral blood by flow cytometry (left y-axis) and qPCR (right y-axis). (E) Contrast-enhanced MRI performed before and after (8 and 12 weeks) the infusion of CAR T-cells.