Table 5.

Hazard ratios (HRs) and 95% CIs for the association between the combination of dietary inflammatory index and dietary oxidative balance score and risk of breast cancer stratified by selected factors

				Combination of dietary inflammatory index and dietary oxidative balance score			P for interaction
Characteristic		Person-years	No. of cases	Anti-inflammatory and anti-oxidative diet	Either	Pro-inflammatory and pro-oxidative diet
Time varying menopausal status	Premenopausal	32299	443	1 (ref)	0.69 (0.53–0.91)	0.65 (0.49–0.87)	0.001
	Postmenopausal	64314	2172	1 (ref)	1.15 (1.03–1.27)	1.20 (1.05–1.37)
Race/ethnicity	Non-Hispanic White	316583	2281	1 (ref)	1.08 (0.97–1.19)	1.07 (0.94–1.22)	0.23
	Non-Hispanic Black	25916	175	1 (ref)	1.26 (0.81–1.97)	1.41 (0.87–2.30)
	Other than White or Black	23915	158	1 (ref)	1.38 (0.84–2.27)	1.73 (1.01–2.97)
No. of first-degree relatives diagnosed with breast cancer before age 50 years	0	154035	1104	1 (ref)	1.15 (1.00–1.32)	1.07 (0.89–1.29)	0.31
	≥1	212379	1510	1 (ref)	1.06 (0.93–1.21)	1.14 (0.98–1.34)
Body mass index, kg/m2	Normal weight (<25 and ≥18.5)	147118	963	1 (ref)	0.98 (0.84–1.14)	0.92 (0.75–1.12)	0.05
	Overweight/obese (≥25)	219296	1651	1 (ref)	1.19 (1.05–1.36)	1.28 (1.10–1.48)
Physical activity	High*	85659	606	1 (ref)	0.96 (0.80–1.15)	0.96 (0.74–1.25)	0.17
	Low to moderate	280755	2008	1 (ref)	1.17 (1.04–1.32)	1.20 (1.05–1.38)
Alcohol consumption	Non/ past drinker	300882	2160	1 (ref)	1.27 (1.01–1.60)	1.42 (1.07–1.88)	0.24
	Current drinker	65532	454	1 (ref)	1.06 (0.95–1.18)	1.07 (0.94–1.22)

Adjusted for covariates used in Table 3 except each stratified variable.

^*Total metabolic equivalent 21+ hours/week for leisure-time physical activity, corresponding to 420+ min per week of moderate-intensity physical activity.