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. 2021 Jun 21;12:642452. doi: 10.3389/fendo.2021.642452

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Copyright © 2021 Yang, Xu, Tan, Li, Zhu, Wang, Sun, Liu, Zheng, Zhu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association between CysC and organ dysfunction and all-cause death in diabetes population classified by sex. (A) The association between CysC and organ dysfunction and all-cause death in the male diabetes population. (B) The association between CysC and in the female diabetes population. Severe inflammation was defined as the highest NLR >6.11 during hospitalization; liver injury was defined as a level of ALT >40 U/L at any time during hospitalization; and heart failure was defined as the highest level of NT-proBNP>300 pg/mL during hospitalization. Adjusted by age, severe pneumonia, serum albumin, blood glucose, log NT-proBNP baseline. T2DM, type 2 diabetes mellitus; CysC, cystatin C; NLR, neutrophil-to-lymphocyte ratio; ALT, alanine aminotransferase; AST, aspartate aminotransferase; NT-proBNP, N terminal pro B type natriuretic peptide.