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. 2021 Jun 21;12:685631. doi: 10.3389/fphar.2021.685631

FIGURE 1.

FIGURE 1

Effects of acute systemic sCT administration on nicotine-induced behaviours in male mice (A) Nicotine (Nic, 0.5 mg/kg, IP) caused locomotor stimulation in mice pre-treated with vehicle (Veh), but not in mice pre-treated with sCT (5 μg/kg, IP) (*p < 0.05 and n. s. not significant) (B) Dopamine release in the NAc shell induced by nicotine (0.5 mg/kg, IP) was higher in mice pre-treated with vehicle compared to those pre-treated with sCT (5 μg/kg, IP) at the time points of 60, 100, 140, and 180 min (*p < 0.05, **p < 0.01) (C) Nicotine-induced (0.5 mg/kg, IP) reward and (D) nicotine reward-dependent memory retrieval in the CPP paradigm was not affected by sCT (5 μg/kg, IP) compared to vehicle (Veh) (n. s. not significant). Data are presented as mean ± SEM.