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. 2021 Jun 21;12:691936. doi: 10.3389/fphar.2021.691936

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Copyright © 2021 Dalvi, Ravi and Uppuluri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma and brain pharmacokinetic performance of formulations. (A): Mean concentration time profiles of Rufinamide obtained following intranasal administration of Rufi-NP-Susp, Rufi-NP-RXG, and Rufi-Susp in plasma; (B): Mean concentration time profiles of Rufinamide obtained following intranasal administration of Rufi-NP-Susp, Rufi-NP-RXG, and Rufi-Susp in the brain. Note: Each data point is a representation of mean ± SD of n = 4 animals for plasma PK, and for brain PK n = 4 animals were used at every time point.