Figure 3A-B:
Leave-one-out analysis to identify variants contributing the most to the burden test association signal in European Americans (3A) and African Americans (3B). Bars represent the minor allele frequency of variants and line-dots show the SKAT burden –Log (p-value) in absence of that specific variants. In European Americans, Chr1:156877520 (rs149254521), Chr1:156877785 (rs757375280), Chr1:156878044 (rs147639000) and Chr1:156882757 (rs41299597) contributed the most to the burden signal. In African Americans, Chr1:156877782 (rs145275734) has the most contribution to the burden signal.