Table 2. Dose recommendations and possible adjust of the drugs used to treat covid-19.

Drugs	Recommended doses12 , 13 , 14 , 15 , 16 , 17 , 40	Dose adjustment (GFR mL/min)15 , 16 , 18			Dialysis15 , 16 , 18
		50-31	30-10	< 10	APD/CAPD	HD	HDF/AF	CAV/VVHD
Chloroquine	Day 1: 450 mg bid PO Days 2 to 5: 450 mg once per day PO	Usual dose	Usual dose	50% of the dose	ND	ND	NR	ND
Hydroxychloroquine	Day 1: 400 mg bid PO Days 2 to 5: 400 mg once per day PO	Usual dose	50% of the dose	50% of the dose	ND	ND	NR	NR
Azithromycin	500 mg once per day PO for 5 days	No adjustment			ND	NR	NR	NR
Nitazoxanide	600 mg bid PO for 5 days	No adjustment			NR	NR	NR	NR
Ivermectin	200 mcg/kg single dose, can be repeated on day 7	No adjustment			NR	NR	NR	NR
Dexamethasone	6 mg once per day PO or IV for 10 days	No adjustment			ND	ND	NR	I
Methylprednisolone	1-2 mg/kg once per day IV for 5-7 days	No adjustment			D (dose usual)	D (dose usual)	D (dose usual)	D (dose usual)
Tocilizumab	8 mg/kg (maximum of 800 mg) IV single dose, can be repeated 1-2 times if there is no clinical improvement within 24 hours	No adjustment			NR	NR	NR	NR
Unfractionated heparin	10.000-15.000 U once per day	No adjustment			ND	ND	ND	ND
Enoxaparin	P: 40 mg once per day* SQ T: 0,5-1 mg/kg bid SQ	Usual dose	P: 20-30 mg/day T: 0,5-1mg/kg/day	P: 20-30 mg/day T: 0,5-1mg/kg/day	ND	ND	D (dose GFR < 30)	ND
Lopinavir/ Ritonavir	400 mg/100 mg once per day PO for 10-14 days	No adjustment			L: I R: ND	L: I R: ND	L: I R: ND	L: NR R: I
Oseltamivir	75 mg bid PO for 5 days	30 mg bid	30 mg/day	30 mg single dose	D (30 mg)	D (30 mg)	D**	D (30 mg)
Favipiravir	Day 1: 1600 mg bid PO Days 2 to 7 to 14: 600 mg bid PO	No adjustment			NR	NR	NR	NR
Remdesivir	Day 1: 200 mg once per day IV Days 2 to 5 or 10: 100 mg once per day IV	Usual dose	Not recommended	Not recommended	NR	NR	NR	NR

Legends: APD/CAPD (automated peritoneal dialysis/continuous ambulatory peritoneal dialysis); bid (twice a day); CAV/VVHD (continuous arteriovenous hemofiltration/veno-venous hemofiltration); D (dialyzed); GFR (glomerular filtration rate); HD (intermittent hemodialysis); HDF/AF (intermittent hemodialysis/high flow); PO (oral administration); I (improbable); IV (intravenous administration); L (lopinavir); ND (not dialyzed); NR (not reported); P (prophylaxis); R (ritonavir); SQ (subcutaneous administration); T (treatment).

^*Body Mass Index (BMI) ≥ 40 kg/m2: increase the dose in about 30%; or 0.5 mg/kg/day using current weight for the calculation.

^**Flow Rate 1-1.8 L/hr: 30 mg/day, flow rate 1.9-3.6 L/hr: 30 mg bid, flow rate > 3.6 L/hr: 75 mg bid.