Table 3.
Tornado diagram* (Point-of-Care COIVD-19 antigen testing versus the conventional clinical approach).
| Variable Name | Variable Description | Lowest value | Basecase value | Highest value | Saving (€) at lowest value | Saving (€) at highest value | Spread Ƭ | Risk%¥ | Cum Risk% |
|---|---|---|---|---|---|---|---|---|---|
| Clin_spec_COVID | Probability of correctly excluding SARS-CoV-2 | 0.60 | 0.683 | 0.758 | −261.47 | −168.38 | 93.08 | 0.53 | 0.53 |
| cOpp_POCT | Opportunity costs due to blocking twin bed | 522.74 | 690.92 | 829.10 | −169.13 | −248.26 | 79.12 | 0.38 | 0.90 |
| Sofia_COVID_spec | Real life specificity of Sofia testing | 0.958 | 0.989 | 0.998 | −194.19 | −217.93 | 23.74 | 0.03 | 0.94 |
| COVID_prev | Prevalence of SARS-CoV-2 | 0.079 | 0.156 | 0.412 | −230.58 | −207.15 | 23.43 | 0.03 | 0.97 |
| cRev_day_POCT | Additional revenue per day due to POCT | 259.13 | 323.91 | 388.69 | −204.48 | −220.65 | 16.17 | 0.02 | 0.99 |
| Sofia_COVID_sens | Real life sensitivity of Sofia test | 0.644 | 0.80 | 0.909 | −204.91 | −217.92 | 13.01 | 0.01 | 1.00 |
| cSofia_COVID | Costs of Sofia test | 9.60 | 12.00 | 14.40 | −215.27 | −209.87 | 5.40 | 0.00 | 1.00 |
| cRT_PCR_ext | Costs of RT-PCR in external laboratory | 42.74 | 42.74 | 51.29 | −213.64 | −212.57 | 1.07 | 0.00 | 1.00 |
| Clin_sens_COVID | Sensitivity of diagnosing SARS-CoV-2 infection | 0.729 | 0.806 | 0.869 | −212.96 | −212.09 | 0.87 | 0.00 | 1.00 |
| cAntithromb_day | Costs of enaxaparin per day | 5.67 | 7.09 | 8.51 | −212.20 | −212.94 | 0.73 | 0.00 | 1.00 |
| sec_COVID | Secondary cases due to one unknown COVID-19 case | 0.013 | 0.025 | 0.050 | −212.61 | −212.61 | 0.06 | 0.00 | 1.00 |
| sick_days | Number of days of HCW out of work due to COVID-19 | 15.00 | 15.00 | 27.00 | −212.57 | −212.60 | 0.03 | 0.00 | 1.00 |
| cPL_day | Costs of productivity loss per day | 134.06 | 167.58 | 201.10 | −212.56 | −212.58 | 0.01 | 0.00 | 1.00 |
| pVacc_eff_COVID_HCW | Probability of effectively vaccinated health care workers | 0.6355 | 0.6360 | 0.6363 | −212.57 | −212.57 | 0.00 | 0.00 | 1.00 |
| pHosp | Probability that hospitalization is required | 0.097 | 0.1010 | 0.1050 | −212.57 | −212.57 | 0.00 | 0.00 | 1.00 |
⁎
One-way sensitivity analyses of all model variables arranged in order, with the variable with the biggest impact at the top and the variable with the smallest impact at the bottom.
¥
Risk%: This is a measure of how much of the total uncertainty is represented by the respective variable. The Risk% values sum to 1.0 across all the variables.
Ƭ
Highest cost saving minus lowest cost saving in €.