Table 1.
Demographics of patients with HCM and single MYBPC3 VUS.
| STRUM (+) n = 39 (37%) | STRUM (−) n = 66 (63%) | p value STRUM (+) vs. STRUM (−) | |
|---|---|---|---|
| Baseline characteristics | |||
| Female, n (%) | 10 (26%) | 14 (21%) | 0.6308 |
| Age at diagnosis, mean (STD), year | 40.31 (17.13) | 41.34 (21.17) | 0.9930 |
| Follow-up time, mean (STD), year | 9.82 (10.00) | 12.18 (11.83) | 0.7575 |
| Maximum BMI, mean (STD) kg/m2 | 28.87 (4.10) | 27.96 (6.03) | 0.9390 |
| lb/ft2 | 685.09 (97.29) | 663.49 (143.09) | |
| Race, n % | 0.5107 | ||
| White | 35 (90%) | 60 (91%) | |
| Black | 2 (5%) | 1 (2%) | |
| Other/not reported | 2 (5%) | 5 (8%) | |
| Proband, n (%) | 35 (90%) | 64 (97%) | 0.1232 |
| Family history HCM, n (%) | 13 (33%) | 19 (29%) | 0.6249 |
| Family history SCD n (%) | 8 (21%) | 9 (14%) | 0.3553 |
| Echocardiogram data | |||
| Maximal LVWT, mean (STD), mm | 22.73 (6.97) | 20.83 (7.29) | 0.4287 |
| Minimum LVEF, mean (STD), % | 59.88 (8.32) | 60.12 (11.34) | 0.9996 |
| LVOT peak gradient ≥30 mmHg; n (%) | 9 (23%) | 21 (32%) | 0.3380 |
BMI body mass index, HCM hypertrophic cardiomyopathy, LVEF left ventricular ejection fraction, LVWT left ventricular wall thickness, LVOT left ventricular outflow tract, SCD sudden cardiac death, VUS variant of uncertain significance.