Fig. 2. Schematic representation of azacitidine and decitabine uptake and metabolism.

5-aza-U 5-aza-uridine, 5-aza-dU 5-aza-2´-deoxyuridine, CDP cytidine diphosphate, CMP cytidine monophosphate, hCNT human concentrative nucleoside transporter, hENT human equilibrative nucleoside transporter, NDPK nucleoside diphosphate kinase, NMPK nucleoside monophosphate kinase, RNR ribonucleotide reductase.