Fig. 3. miR-10a expression is correlated to MDM2 inhibitor sensitivity in vitro.

a The endogenous expression of miR-10a in the NCI-60 cell line panel was correlated to sensitivity to 265 drugs screened in GDSC and Nutlin-3a was found to have the 4th strongest positive correlation with an r² value of 0.17 (p < 0.05). b NCI-60 cell lines with endogenous expression below the median level had a mean IC₅₀ of 34.1 µM, versus 95.7 µM for those above. c miR-10a displayed bimodal expression in 86 NPM1^wt primary AML specimens assayed at diagnosis. (*p < 0.05, **p < 0.01; ***p < 0.001 by Student’s T test with error bars representing SD).