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. 2021 May 10;5(7):927–938. doi: 10.1038/s41559-021-01448-6

Fig. 6. Functionally complete and specific gene expansion in the N. pompilius immune system.

Fig. 6

a, Schematic representation of molecular components in the TLR and TNFR signalling pathways. AP-1, activator protein 1; IKK, inhibitor of nuclear factor kappa-B kinase; IRAK, interleukin-1 receptor-associated kinase; JNK, c-Jun NH2-terminal kinase; MKK, mitogen-activated protein kinase kinase; Myd88, myeloid differentiation primary response 88; NF-κB, nuclear factor kappa-B; NOS, nitric oxide synthase; TAK1, transforming growth factor-β-activated kinase 1; TRAF6, TNFR-associated factor 6; TRAK, trafficking kinesin-binding protein. b, Distribution of TLR and TNFR signalling pathway components in representative cephalopod species. Gene numbers are represented by spheres of different sizes and colours. c, Phylogeny of C-type lectin in cephalopod species. The different colours in the circle represent distinct species. N. pompilius-specific expanded clades are labelled in light red.