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. 2021 Jun 21;9:685741. doi: 10.3389/fcell.2021.685741

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Copyright © 2021 Xiao, Yin, Wang, Yang, Ma, Pan and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression profiles of exosome-circRNAs from RNA-Seq. (A) Various RNA biotypes expressed as a percentage of the total sequencing reads by taking the average reads of each biotype across each group. (B) circRNAs from exons, introns, or intergenic regions. (C) The lengths of circRNAs in each subject. (D) Volcano plots of differentially expressed circRNAs. The red and green dots indicate upregulated and downregulated circRNAs, respectively. (E) Heat maps of differentially expressed circRNAs.