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. 2021 Jun 1;78(13):5341–5370. doi: 10.1007/s00018-021-03846-2

Table 5.

Properties conferred by the “first subunit class” of the receptor

isoform α1 α2 α3 α4 α5 α6
GABA EC50 Medium Medium Very high Medium Medium Very low
Desensitization Complete and moderately fast Complete and moderately fast Slow and incomplete Fast and complete Slow and incomplete Medium speed and complete
Refractory period Long Medium Medium Short Short Very long
Deactivation Moderately fast Moderately slow Very slow Very fast Fast Slow
Activation Fast Moderately fast Slow Medium Moderately slow Medium