Table 3.
Aerobic capacity+ (n=48) | Aerobic capacity- (n=28) | P value | |
Echocardiography | |||
RA reservoir strain, % | 3.2±1.1 | 0.4±0.7 | <0.001 |
RA volume index, mL/m2 | −16±5 | −18±7 | 0.4 |
RA reservoir strain/RA max volume | 0.31±0.1 | 0.12±0.1 | <0.001 |
RV global longitudinal strain,% | 2.6±1.9 | 1.3±1.7 | 0.2 |
TAPSE, mm | −3±2 | −2±2 | 0.5 |
RV s’, cm/s | 2±1 | 2±2 | 0.4 |
RV fractional area change, % | −5±3 | −7±4 | 0.2 |
IVC collapsibility,% | 18±11 | 11±9 | 0.004 |
Estimated RA pressure, mm Hg | −2.4±1.1 | −1.3±1.9 | 0.02 |
LA reservoir strain, % | 1.9±0.5 | 1.1±0.8 | 0.008 |
LA reservoir strain/LA max volume | 0.1±0.1 | 0.1±0.1 | 0.9 |
LV end-diastolic volume index, mL/m2 | 8±3 | 5±3 | <0.001 |
LV end-systolic volume index, mL/m2 | 2±1 | 2±2 | 0.9 |
LV stroke volume index, mL/m2 | 6±3 | 3±2 | <0.001 |
LV ejection fraction, % | 3±2 | 3±3 | 0.7 |
LV global longitudinal strain, % | −0.6±0.8 | −0.4±0.6 | 0.4 |
Diastolic LV eccentricity index | −0.31±0.19 | −0.22.±0.13 | 0.03 |
Lateral mitral E/e’ | −1±1 | −1±1 | 0.9 |
Exercise test | |||
Peak VO2, mL/kg/min | 2.1±1.4 | −0.9±0.4 | <0.001 |
Predicted peak VO2, % | 6±2 | −3±2 | <0.001 |
Predicted peak heart rate, % | 3±2 | 3±2 | 0.9 |
Oxygen pulse, mL | 2.3±1.1 | 1.1±2.3 | 0.006 |
VE/VCO2 slope | −3±2 | −2±3 | 0.2 |
Oxygen saturation at rest, % | 0±1 | 0±1 | 0.9 |
Oxygen saturation at peak, % | 1±1 | 2±1 | 0.7 |
E/e’, ratio of mitral inflow pulsed wave Doppler early velocity to mitral annular tissue Doppler early velocity; IVC, inferior vena cava; LA, left atrium; LV, left ventricle; RA, right atrium; RV, right ventricle; TR, tricuspid regurgitation; VE/VCO2, ventilatory equivalent for carbon dioxide; VO2, oxygen consumption.